| Project/Area Number |
15K14728
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
Komai Michio 東北大学, 農学研究科, 教授 (80143022)
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| Co-Investigator(Kenkyū-buntansha) |
後藤 知子 東北大学, 農学研究科, 助教 (00342783)
白川 仁 東北大学, 農学研究科, 准教授 (40206280)
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| Co-Investigator(Renkei-kenkyūsha) |
ISONO KUNIO 東北大学, 大学院農学研究科, 技術補佐員 (70124550)
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| Research Collaborator |
YAMAKI MICHIKO 東北生活文化大学, 助教
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 苦味受容体 / ＴＡＳ２Ｒ３８ / 消化器癌患者 / 健常者 / 苦味感受性 / グルタチオン-S トランスフェラーゼ（ＧＳＴ） / TAS2R38 / TAS2R46 / phenylthiocarbamide（PTC） / TAS2R / bitter taste receptor / GSH S-transferase / gene polymorphism / cruciforous plant |
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| Outline of Final Research Achievements |
The involvement of bitter taste receptor, TAS2Rs in cancers has not been well understood. So, we conducted a pilot study by genotyping two TAS2R genes, TAS2R38 and TAS2R46, in Japanese cancer patients diagnosed with the digestive cancer. As a results, we confirmed that phenylthiocarbamide (PTC) non-tasters homozygous (AVI/AVI) for TAS2R38 were more frequent among Japanese cancer patients than those among control subjects, which indicates that the AVI/AVI genotype for TAS2R38 was therefore considered to increase cancer risk.
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