Project/Area Number |
15K14728
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Food science
|
Research Institution | Tohoku University |
Principal Investigator |
Komai Michio 東北大学, 農学研究科, 教授 (80143022)
|
Co-Investigator(Kenkyū-buntansha) |
後藤 知子 東北大学, 農学研究科, 助教 (00342783)
白川 仁 東北大学, 農学研究科, 准教授 (40206280)
|
Co-Investigator(Renkei-kenkyūsha) |
ISONO KUNIO 東北大学, 大学院農学研究科, 技術補佐員 (70124550)
|
Research Collaborator |
YAMAKI MICHIKO 東北生活文化大学, 助教
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 苦味受容体 / TAS2R38 / 消化器癌患者 / 健常者 / 苦味感受性 / グルタチオン-S トランスフェラーゼ(GST) / TAS2R38 / TAS2R46 / phenylthiocarbamide(PTC) / TAS2R / bitter taste receptor / GSH S-transferase / gene polymorphism / cruciforous plant |
Outline of Final Research Achievements |
The involvement of bitter taste receptor, TAS2Rs in cancers has not been well understood. So, we conducted a pilot study by genotyping two TAS2R genes, TAS2R38 and TAS2R46, in Japanese cancer patients diagnosed with the digestive cancer. As a results, we confirmed that phenylthiocarbamide (PTC) non-tasters homozygous (AVI/AVI) for TAS2R38 were more frequent among Japanese cancer patients than those among control subjects, which indicates that the AVI/AVI genotype for TAS2R38 was therefore considered to increase cancer risk.
|