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Search for intestinal epithelial cell-derived membrane proteins interacting with dietary fiber

Research Project

Project/Area Number 15K14729
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionGifu University

Principal Investigator

YABE Tomio  岐阜大学, 応用生物科学部, 教授 (70356260)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsペクチン / 腸管上皮細胞 / 食物繊維 / フィブロネクチン / 膜タンパク質
Outline of Final Research Achievements

Dietary fiber is a natural health food ingredient, and has attracted a great deal of attention recently, in particular as a food material for preventing lifestyle diseases. It is clarified that the physiological function brought by dietary fiber is an action on gastrointestinal function, which is reported that dietary fiber affects interaction with intestinal contents, villus morphology, and the function of digestion and absorption in the small intestine. In this research project, we focused on the fact that dietary fiber affects physiologically active substance locally secreted in the gastrointestinal tract and is involved in cell proliferation, and we attempted to identify proteins interacting with pectin in vivo. But we could not get anything highly. We are planning to continue exploring in the future.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] 腸管上皮由来フィブロネクチンと相互作用するペクチン部分構造の解明2017

    • Author(s)
      中 智美,宮本 茉由,山根 菜摘,北口 公司,矢部 富雄
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腸管免疫へのプロローグ:食物繊維と腸管構成細胞との相互作用2017

    • Author(s)
      矢部富雄
    • Organizer
      日本農芸化学会2017年度大会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pectin from Prunus domestica L. induces proliferation of intestinal cells through the alteration of cell-surface heparan sulfate on differentiated epithelial cells in vitro2016

    • Author(s)
      Tomio Yabe, Mitsutaka Nishida, Toshinari Kuwae, Mayu Miyamoto, Natsumi Yamane, and Kohji Kitaguchi
    • Organizer
      1st Food Chemistry Conference
    • Place of Presentation
      Amsterdam
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腸管上皮細胞由来フィブロネクチント相互作用するペクチンの部分構造の解明2016

    • Author(s)
      中智美,宮本茉由,山根菜摘,北口公司,矢部富雄
    • Organizer
      日本農芸化学会中部支部第177回例会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペクチン分子中のフィブロネクチンと相互作用する多糖構造の解析2016

    • Author(s)
      宮本茉由,山根菜摘,岩本悟志,北口公司,矢部富雄
    • Organizer
      日本応用糖質科学会平成28年度大会(第65回)
    • Place of Presentation
      福山
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘパラン硫酸糖鎖構造変化を介したペクチンによる腸管上皮細胞応答の解明2016

    • Author(s)
      桑江俊成,西田光貴,伊藤千弘,北口公司,矢部富雄
    • Organizer
      日本糖質学会第35回年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペクチンによる細胞表面糖鎖構造変化の誘導機構の解析2016

    • Author(s)
      下吉美澄,西田光貴,村田一馬,北口公司,矢部富雄
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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