| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It has been known that the number of chewing decreases greatly in modern society, and the decrease in chewing is thought to exacerbate our health condition. Because there is no animal experiment model, no molecular biological research such as what is happening in the body has been done at all. We developed for the first time a chewing suppression animal model by a method of covering anterior teeth with a resin for human temporary teeth in rats. In this study, we focus on not only the mechanical movement of teeth and muscles in mastication but also saliva containing growth factors, and clarify the nutritional significance of chewing. We analyze the cell proliferative capacity and the deterioration of lipid metabolism in the liver/gastrointestinal tract controlled by chewing at the molecular level to establish this chewing suppression animal model.
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