| Project/Area Number |
15K14781
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Aquatic bioproduction science
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| Research Institution | Kagoshima University |
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Principal Investigator |
UNO Seiichi 鹿児島大学, 農水産獣医学域水産学系, 准教授 (50381140)
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| Co-Investigator(Kenkyū-buntansha) |
横山 佐一郎 鹿児島大学, 農水産獣医学域水産学系, 助教 (60437952)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アスコルビン酸 / 酸化ストレス / コラーゲン / 抗酸化作用 / 奇形誘発 / ヒメダカ / OxyPAH / 魚胚 / 奇形 / 魚類胚 / oxyPAHs |
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| Outline of Final Research Achievements |
In the present study, we examined the role of ascorbic acid (AsA) as the defense-component in fish exposed to chemicals. Medaka fish were fed the artificial food with small amount of AsA or without AsA. The malformation rate in the hatching larvae from embryos spawned by those fish tended to increase with decreasing the contents of AsA in embryos. This result suggests that AsA is absolutely necessary for the formation of collagen. When AsA contents in embryos became low, several effects were caused in embryos even by lower concentration of Oxygenated PAH. Because AsA reacting as the antioxidant and catalyst at the formation of collagen were shortage in embryos, those effects were caused even in low exposure concentration of OxyPAH. As a result, we showed that AsA is absolutely necessary for the defense-component to the exposure of chemicals.
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