| Project/Area Number |
15K14843
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
Kiyoshi OKUDA 帯広畜産大学, その他部局等, 学長 (40177168)
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| Co-Investigator(Kenkyū-buntansha) |
木村 康二 岡山大学, 環境生命科学研究科, 教授 (50355070)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 卵管 / ウシ / 繊毛 / 平面内細胞極性 |
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| Outline of Final Research Achievements |
Uni-directional ciliary beating is required for successful transport of oocytes and embryos. In some tissues including airway and skin, planar cell polarity (PCP) signaling arranges the direction of cells throughout these tissues. In the present study, we demonstrated that VANGL1, one of PCP core protein, is localized in the ovarian and uterus sides of the cellular membranes of bovine oviductal ciliated cells. Additionally, DVL3 and Inturned, which are the downstream proteins of VANGL1, are also localized in the ciliated cells. These series of VANGL1 signaling may arrange the direction of ciliated cells and cilia throughout the whole tissues from distal to proximal, producing the stream of oviductal fluid toward the uterus to transport the oocytes and embryos.
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