| Project/Area Number |
15K14857
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中嶋 秀満 大阪府立大学, 生命環境科学研究科, 准教授 (30405360)
東 泰孝 大阪府立大学, 生命環境科学研究科, 准教授 (50298816)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬理 / 神経科学 / シグナル伝達 / 脳神経疾患 / 獣医学 / ポリADPリボース / グリア細胞 / 神経栄養因子 / ＧDNF / 神経保護 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of extracellular poly(ADP-ribose) (EC-PAR) in the pathophysiology of neurodegenerative disorders. PAR is synthesized by PAR polymerase-1 (PARP-1) and released into the extracellular space during PARP-1-induced cell death. In vitro, treatment of rat astrocytes with EC-PAR increased the synthesis and release of glial cell line-derived neurotrophic factor (GDNF) but not other neurotrophic factors. In vivo, topical injection of EC-PAR into the striatum of a Parkinson disease rat model upregulated GDNF levels in activated astrocytes and improved pathogenic rotation behavior. Because GDNF is known to be neuroprotective in cases of Parkinson disease, administration of EC-PAR could potentially be used to treat this devastating disease.
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