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Pioneering study of genome analysis in canine malignant tumors to establish a clinical genome-based diagnostics

Research Project

Project/Area Number 15K14864
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Watanabe Manabu  東京大学, 大学院新領域創成科学研究科, 准教授 (70376606)

Co-Investigator(Renkei-kenkyūsha) TSUBOI Masaya  東京大学, 大学院農学生命科学研究科, 助教 (20721963)
NAKAGAWA Takayuki  東京大学, 大学院農学生命科学研究科, 准教授 (40447363)
TSUJIMOTO Hajime  東京大学, 大学院農学生命科学研究科, 教授 (60163804)
NISHIMURA Ryohei  東京大学, 大学院農学生命科学研究科, 教授 (80172708)
SUGANO Sumio  東京大学, 大学院新領域創成科学研究科, 教授 (60162848)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords臨床がんゲノム診断 / イヌ / トランスレーショナルリサーチ / ゲノム治療 / オーダーメイド医療 / がん体質 / マルチプレックスPCR / 診断型シークエンサー
Outline of Final Research Achievements

In the study, we performed clinical cancer genome analysis to reveal the molecular mechanisms of canine tumors, and establish clinical diagnosis using multiple genotyping system. As the results of the study, we could detect a lot of genomic alteration from a trace of a DNA sample using multiplex PCR methods and next-generation sequencer. In a genomic coding region of BRCA2, which is responsible gene of a human hereditary breast/ovarian cancer syndrome, we detected 26 regions in 7 kinds of tumors including 52 tumor bearing patients, and some of the detected BRCA2 mutations might be related to tumor malignancies. In SNP genotyping analysis, we demonstrated that one of the BRCA2 variant could be a chihuahua breed unique genomic variants. These results suggested that the understanding of canine tumors and contribution to clinical applications.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] イヌゲノム研究の現状と課題と展望 -イヌと起源、形質、遺伝病、がん-2016

    • Author(s)
      渡邊 学
    • Journal Title

      動物遺伝育種研究

      Volume: 44 Pages: 69-85

    • NAID

      130005263077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Genomic Analysis on Tissues and Plasma of Canine Hepatocellular Tumors2016

    • Author(s)
      Yuiko TANAKA, Manabu WATANABE, Tetsugo TASAKA, Kohei SAEKI, Masaya TSUBOI, Takayuki NAKAGAWA, Ryohei NISHIMURA, Sumio SUGANO
    • Organizer
      Asian Society of Veterinary Surgery
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cancer Genome Analysis using Diagnostic Next Generation Sequencer (NGS) in Canine Hepatic Tumors2016

    • Author(s)
      Yuiko TANAKA, Manabu WATANABE, Tetsugo TASAKA, Masaya TSUBOI, Kohei SAEKI, Takayuki NAKAGAWA, Ryohei NISHIMURA, Sumio SUGANO
    • Organizer
      Veterinary Cancer Society
    • Place of Presentation
      Florida (USA)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genomic Sequencing of Canine Hepatocellular Carcinoma2016

    • Author(s)
      Yuiko TANAKA, Manabu WATANABE, Tetsugo TASAKA, Yasuyuki KAWABATA, Kohei SAEKI, Masaya TSUBOI, Takayuki NAKAGAWA, Ryohei NISHIMURA, Sumio SUGANO
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラパチニブ投与により長期生存を示した臨床乳腺腫瘍症例とその分子病態解析2016

    • Author(s)
      渡邊学 田中由依子 田坂徹悟 坪井誠也 内田和幸 中川貴之 辻本元 西村亮平 菅野純夫
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学藤沢キャンパス(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学大学院新領域創成科学研究科メディカル情報生命専攻ゲノムシステム医療科学分野(菅野研)

    • URL

      http://ssmgs.net/lab/

    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://ssmgs.net/lab/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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