Roles of transient receptor potentials in itch and inflammation in allergic status

• Project/Area Number: 15K14867
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Tanaka Akane 東京農工大学, (連合)農学研究科(研究院), 教授 (80418673)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 臨床病理 / アトピー性皮膚炎

Outline of Final Research Achievements

Peripheral perception, including sensations of pain and itch, functions as host protection from external stimuli. However, over or abnormal activation of peripheral neuronal systems sometimes induce unpleasant sensation to hosts. Although itch sensation is one of the most unbearable clinical symptoms in patients with atopic dermatitis, the exact mechanism that maintains chronic itch in allergic status has not been fully understood. Recent studies have suggested the role of TRP channels in itch sensation appeared in allergic skin diseases. Therefore, in the present study, we attempted to investigate association of TRP channels in pathogenesis of atopic dermatitis by using TRP channels deficient NC/Tnd mice.

Research Products

• [Int'l Joint Research] ウイーン医科大学(オーストリア)
• [Int'l Joint Research] マンチェスター大学(英国)
• [Int'l Joint Research] 全南大学(韓国)
• [Int'l Joint Research] マンチェスター大学(英国)
• [Int'l Joint Research] チェジュ大学(韓国)
• [Journal Article] Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH. (2017)
  • Author(s): Oida K, Einhorn L, Herrmann I, Panakova L, Resch Y, Vrtala S, Hofstetter G, Tanaka A, Matsuda H, Jensen-Jarolim E.
  • Journal Title: WAO J. Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp. (2016)
  • Author(s): Jang H, Makita Y, Jung K, Ishizaka S, Karasawa K, Oida K, Takai M, Matsuda H, Tanaka A.
  • Journal Title: J Appl Microbiol. Volume: 120 Issue: 2 Pages: 280-288
  • DOI: 10.1111/jam.13012
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Skin pH is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model. (2016)
  • Author(s): Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A.
  • Journal Title: J. Invest. Dermatol. Volume: 136 Issue: 1 Pages: 127-136
  • DOI: 10.1038/jid.2015.363
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ultra-pure Soft Water Ameliorates Atopic Skin Disease by Preventing Metallic Soap Deposition in NC/Tnd Mice and Reduces Skin Dryness in Humans. (2015)
  • Author(s): Tanaka A, Matsuda A, Jung K, Jang H, Ahn G, Ishizaka S, Amagai Y, Oida K, Arkwright PD, Matsuda H.
  • Journal Title: Acta Derm Venereol. Volume: In press Pages: 787-791
  • DOI: 10.2340/00015555-2083
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice. (2015)
  • Author(s): Amagai Y, Oida K, Matsuda A, Jung K, Kakutani S, Tanaka T, Matsuda K, Jang H, Ahn G, Xia Y, Kawashima H, Shibata H, Matsuda H, Tanaka A.
  • Journal Title: J. Dermatol. Sci. Volume: In press Issue: 1 Pages: 30-37
  • DOI: 10.1016/j.jdermsci.2015.03.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Filaggrin-independent development of allergic skin lesions in the mouse model for human atopic dermatitis. (2016)
  • Author(s): Tanaka A, Jang H, Matsuda H
  • Organizer: 欧州アレルギー臨床免疫学会2016
  • Place of Presentation: オーストリア・ウイーン
  • Year and Date: 2016-06-14
  • Int'l Joint Research
• [Presentation] Ultra-pure soft water ameliorates skin conditions of adult and child patients with atopic dermatitis (2015)
  • Author(s): 田中あかね、ジャンヒョション、松田浩珍
  • Organizer: 欧州小児アレルギー学会PAAM2015
  • Place of Presentation: ドイツ・ベルリン
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] アトピー性皮膚炎モデルマウスにおける皮膚pH調節因子の解析 (2015)
  • Author(s): ジャンヒョション、松田浩珍、田中あかね
  • Organizer: 第１５８階日本獣医学会学術集会
  • Place of Presentation: 北里大学（青森県・十和田市）
  • Year and Date: 2015-09-07
• [Remarks] 研究室ホームページ
  • URL: http://web.tuat.ac.jp/~mol_path/