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Screening of candidate genes associating with the progression of chronic kidney disease in mice

Research Project

Project/Area Number 15K14873
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionHokkaido University

Principal Investigator

Ichii Osamu  北海道大学, 獣医学研究科, 准教授 (60547769)

Co-Investigator(Renkei-kenkyūsha) HORINO TARO  高知大学, 医学部, 講師 (90448382)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords慢性腎臓病(CKD) / 嚢胞 / 原因遺伝子 / 遺伝子座 / ゲノム / 病理 / マウス / 遠位尿細管 / 獣医学
Outline of Final Research Achievements

Chronic kidney disease (CKD) is a serious problem from the points of increase of the patients with CKD as well as medical economy. In the present study, we discovered the candidate locus associating with the progression of CKD in DBA/2 mouse inbred strain. We named this locus as DBA/2 renal cyst“drecy”. From the pathological analysis, drecy locus related to the alternation of molecules associating with the transportations of ion or vesicle and cell-adhesion in the epithelial cells of distal tubules. We considered that these alternations would lead the abnormal phenotypes of distal tubules, including cyst formation. Furthermore, gene expression analysis suggested that the genes encoded on DBA/2-type chromosome 12 (D12Mit182-83), in particular Greb1, associate with the progression of these phenotypes.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Remarks (4 results)

  • [Journal Article] Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes2016

    • Author(s)
      Ichii O, Nakamura T, Irie T, Kouguchi H, Nakamura D, Nakamura S, Sato S, Yokoyama K, Horino T, Sunden Y, Elewa YH, Kon Y
    • Journal Title

      Histochemistry and Cell Biology

      Volume: in press Issue: 3 Pages: 351-362

    • DOI

      10.1007/s00418-016-1438-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MRL/MpJ mice show unique pathological features after experimental kidney injury2016

    • Author(s)
      Shiozuru D, Ichii O, Kimura J, Nakamura T, Elewa YH, Otsuka-Kanazawa S, Kon Y
    • Journal Title

      Histology and Histopathology

      Volume: 31(2) Pages: 189-204

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス遠位尿細管の嚢胞形成に関与する新規原因遺伝子座の役割2016

    • Author(s)
      市居 修、中村 鉄平、矢吹 映、堀野 太郎、昆 泰寛
    • Organizer
      第159回 日本獣医学会学術集会
    • Place of Presentation
      神奈川県藤沢市日本大学
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遠位尿細管上皮細胞の形態機能を制御するIL-1F6/IL-36α2016

    • Author(s)
      市居 修、中村鉄平、岡村匡史、木村純平、堀野太郎、昆 泰寛
    • Organizer
      日本解剖学会第62回東北・北海道連合支部学術集会
    • Place of Presentation
      北海道帯広市帯広畜産大学
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 雌性コットンラット(Sigmodon hispidus)にみられる腎性貧血2016

    • Author(s)
      中村 鉄平, 市居 修, 入江 隆夫, 孝口 裕一, 寸田 祐嗣, 堀野 太郎, 昆 泰寛
    • Organizer
      第9回 日本獣医腎泌尿器学会学術集会
    • Place of Presentation
      東京都千代田区連合会館
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遠位尿細管傷害を知らせるマーカー分子“IL-1F6/IL-36a”の有用性2015

    • Author(s)
      市居 修、中村 鉄平、堀野 太郎、木村 純平、岡村 匡史、昆 泰寛
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      青森県十和田市北里大学
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
  • [Remarks] 北大・獣医・解剖学教室ホームページ

    • URL

      https://www.vetmed.hokudai.ac.jp/organization/anat/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 北海道大学研究者総覧

    • URL

      https://researchers.general.hokudai.ac.jp/profile/ja.wkc9JlsishXmgpuI4vfbHA==.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 北大・獣医・解剖学教室ホームページ

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/anat/

    • Related Report
      2015 Research-status Report
  • [Remarks] 北海道大学 研究者総覧

    • URL

      http://researchers.general.hokudai.ac.jp/profile/ja.wkc9JlsishXmgpuI4vfbHA==.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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