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Epigenetic regulation of the development of neural system for nociception by maternal factors

Research Project

Project/Area Number 15K14882
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionAzabu University

Principal Investigator

Mogi Kazutaka  麻布大学, 獣医学部, 准教授 (50347308)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords痛覚 / 発達 / 母性因子 / エピジェネティクス / マウス
Outline of Final Research Achievements

It has been shown that the maternal environment affects the offspring’s development of social behaviors. It has recently suggested that the similar possibility is also seen in nociception. On the other hand, a novel sensory neuron, which was only stimulated by massage-like stroking and express the G-protein-coupled receptor Mrgprb4, was found in 2013. In the present study, we tried to demonstrate our hypothesis that the neural system for nociception was adequately organized by the activation of Mrgprb4-expressing neurons under the maternal factors. As results, we found that pain sensitivity was increased in mice which were nurtured by mothers showing lower licking/grooming rates than usual mothers. Furthermore, when we inhibited the activity of Mrgprb4-expressing neurons in Mrgprb4-cre mice only during early life period until weaning by using the Designer Receptors Exclusively Activated by Designer Drugs (DREDDs), pain sensitivity in those mice increased in adulthood.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Early weaning impairs fear extinction and decreases brain-derived neurotrophic factor expression in the prefrontal cortex of adult male C57BL/6 mice2016

    • Author(s)
      Kazutaka Mogi, Yuiko Ishida, Miho Nagasawa, Takefumi Kikusui.
    • Journal Title

      Dev Psychobiol.

      Volume: 58 Issue: 8 Pages: 1034-1042

    • DOI

      10.1002/dev.21437

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Early weaning impairs a social contagion of pain-related stretching behavior in mice.2016

    • Author(s)
      Takefumi Kikusui, Yukino Ishio, Miho Nagasawa, Jeffrey Mogil, Kazutaka Mogi.
    • Journal Title

      Dev Psychobiol

      Volume: 58 Issue: 8 Pages: 1101-1107

    • DOI

      10.1002/dev.21443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice2016

    • Author(s)
      Tatsuya Hattori, Takuya Osakada, Ayaka Matsumoto, Naoki Matsuo, Sachiko Haga-Yamanaka, Takaya Nishida, Yuji Mori, Kazutaka Mogi, Kazushige Touhara, Takefumi Kikusui
    • Journal Title

      Current Biology

      Volume: 26 Issue: 9 Pages: 1229-1234

    • DOI

      10.1016/j.cub.2016.03.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of behavioral characteristics of dogs in the United States and Japan2016

    • Author(s)
      Miho Nagasawa, Kazutaka Mogi, James Serpell, and Takefumi Kikusui
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 2 Pages: 231-238

    • DOI

      10.1292/jvms.15-0253

    • NAID

      130005131341

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heart rate variability predicts the emotional state in dogs2016

    • Author(s)
      M. Katayama, T. Kubo, K. Mogi, K. Ikeda, M. Nagasawa, T. Kikusui
    • Journal Title

      Behavioural Processes

      Volume: 128 Pages: 108-112

    • DOI

      10.1016/j.beproc.2016.04.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウスの社会行動発達における幼少期オキシトシンの役割2016

    • Author(s)
      茂木一孝
    • Organizer
      平成28年度生理研研究会・第6回社会神経科学研究会『社会のなりたちを支える内分泌学』
    • Place of Presentation
      岡崎
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Identification of social cues in emotional contagion of pain using MSM/Ms and C57BL/6 strains of mice.2016

    • Author(s)
      M. Nakamura, T. Koide, T. Kikusui, K. Mogi, M. Nagasawa
    • Organizer
      76th Annual Meeting of The Japanese Society for Animal Psychology
    • Place of Presentation
      札幌
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Oxytocin forms inter-individual relationship.2016

    • Author(s)
      T. Kikusui, M. Nagasawa, K. Mogi
    • Organizer
      31st International Congress of Psychology
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxytocin is involved in the pheromonal memory formation in the accessory olfactory bulb in mice.2016

    • Author(s)
      陶山 一、土屋 里織、服部 達哉、村田 華奈、内藤 めぐみ、永澤 美保、西森 克彦、茂木 一孝、菊水 健史
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice.2016

    • Author(s)
      服部 達哉、小坂田 拓哉、松元 綾香、松尾 直毅、はが 紗智子、西田 貴也、森 裕司、茂木 一孝、東原 和成、菊水 健史
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      第39回日本神経科学大会
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Early weaning impaired fear extinction and decreased BDNF expression in the prefrontal cortex in adult C57BL/6 mice.2015

    • Author(s)
      K. Mogi, Y. Ishida, M. Nagasawa, T. Kikusui
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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