| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Serotonergic system is involved in many brain functions (circadian rhythm, aggression, feeding behavior, sexual behavior, and so on). Serotonergic neurons project their axons to a whole brain. Although the density of serotonergic axons is locally uniform, how the axonal density is regulated is almost unknown. In the present study, we focused on the protocadherin-alpha (Pcdha) family, which consist of 14 transmembrane proteins and homophilically interact with each other. Here, we generated Pcdha mutant mice, in which members of Pcdha family were reduced, and analyzed them. We found that PcdhaC2, a member of Pcdha family, is essential for normal serotonergic-axon density.
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