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Morphological analyses in sparse labeled neurons

Research Project

Project/Area Number 15K14889
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionNational Institute of Genetics

Principal Investigator

Katori Shota  国立遺伝学研究所, 個体遺伝研究系, 特任研究員 (50562394)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経回路形成 / 遺伝子改変マウス / セロトニン神経 / モザイク解析
Outline of Final Research Achievements

Serotonergic system is involved in many brain functions (circadian rhythm, aggression, feeding behavior, sexual behavior, and so on). Serotonergic neurons project their axons to a whole brain. Although the density of serotonergic axons is locally uniform, how the axonal density is regulated is almost unknown. In the present study, we focused on the protocadherin-alpha (Pcdha) family, which consist of 14 transmembrane proteins and homophilically interact with each other. Here, we generated Pcdha mutant mice, in which members of Pcdha family were reduced, and analyzed them. We found that PcdhaC2, a member of Pcdha family, is essential for normal serotonergic-axon density.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] 神経回路形成におけるRacGAPαキメリンの役割2018

    • Author(s)
      香取将太、岩里琢治
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 36 Pages: 501-503

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance2017

    • Author(s)
      Katori Shota、Noguchi-Katori Yukiko、Itohara Shigeyoshi、Iwasato Takuji
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Issue: 32 Pages: 7682-7699

    • DOI

      10.1523/jneurosci.3123-16.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocadherin-αC2 is required for diffuse projections of serotonergic axons2017

    • Author(s)
      Katori Shota、Noguchi-Katori Yukiko、Okayama Atsushi、Kawamura Yoshimi、Luo Wenshu、Sakimura Kenji、Hirabayashi Takahiro、Iwasato Takuji、Yagi Takeshi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15908-15908

    • DOI

      10.1038/s41598-017-16120-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Midline barrier for axon guidance is protected by EphA4-α-chimaerin signaling in the spinal cord2017

    • Author(s)
      Katori Shota、Noguchi-Katori Yukiko、Itohara Shigeyoshi、Iwasato Takuji
    • Organizer
      Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RacGAP α-chimaerin is required to establish spinal midline barrier for proper corticospinal projection2016

    • Author(s)
      Katori S, Itohara S, Iwasato T
    • Organizer
      International Symposium 2016, Circuit Construction in the Mammalian Brain
    • Place of Presentation
      大阪大学大学院生命機能研究科
    • Year and Date
      2016-08-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spinal cord RacGAP α-chimaerin is critical to maintain midline barrier for proper axon guidance2016

    • Author(s)
      香取将太、糸原重美、岩里琢治
    • Organizer
      第9回神経発生討論会・難治疾患 共同研究拠点 共同開催学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 哺乳類中枢神経系における神経回路形成の遺伝学的解析~神経回路形成におけるRacGAPαキメリンの新たな役割~2016

    • Author(s)
      香取将太、岩里琢治
    • Organizer
      平成27年度脳研究所共同利用共同研究合同セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] α-Chimaerin is required to establish spinal midline barrier for proper corticospinal projection.2016

    • Author(s)
      Katori S, Itohara S, Iwasato T
    • Organizer
      Neuroscience 2016 (Society for Neuroscience)
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 左右の神経回路の混線を防ぐ『正中線バリア』の形成メカニズム2016

    • Author(s)
      香取将太、岩里琢治
    • Organizer
      第11回「認識と形成」研究会
    • Place of Presentation
      名古屋市立大学薬学部
    • Related Report
      2016 Research-status Report
  • [Presentation] 軸索ガイダンスに必要な正中線バリアの形成メカニズム2016

    • Author(s)
      香取将太
    • Organizer
      心生物学シンポジウム
    • Place of Presentation
      大阪大学大学院生命機能研究科
    • Related Report
      2016 Research-status Report
  • [Presentation] Spinal RacGAP α-chimaerin is required to establish midline barrier for proper corticospinal projection2016

    • Author(s)
      Katori S, Itohara S, Iwasato T
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spinal cord RacGAP α-chimaerin is critical to maintain midline barrier for proper axon guidance2015

    • Author(s)
      香取将太、糸原重美、岩里琢治
    • Organizer
      包括型脳科学研究推進支援ネットワーク平成27年度冬のシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-12-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Spinal cord RacGAP α-chimaerin is critical to maintain midline barrier for proper axon guidance2015

    • Author(s)
      香取将太、糸原重美、岩里琢治
    • Organizer
      遺伝研研究会Circuit Construction in the Mammalian Brain
    • Place of Presentation
      静岡
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Cell autonomous and non-autonomous functions of RacGAP α-chimaerin in axon guidance at the midline choice point2015

    • Author(s)
      Shota Katori, Shigeyoshi Itohara, Takuji Iwasato
    • Organizer
      Neuroscience 2015, Society for Neuroscience
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cell autonomous and non-autonomous functions of RacGAP α-chimaerin in midline axonal guidance2015

    • Author(s)
      香取将太、糸原重美、岩里琢治
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      兵庫
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 正中線軸索ガイダンスにおけるRacGAPαキメリンの細胞非自律的な役割~αキメリンは脊髄正中線バリアの隙間を防ぐ~2015

    • Author(s)
      香取将太、糸原重美、岩里琢治
    • Organizer
      第1回「適応シフト回路」領域会議(夏の班会議)
    • Place of Presentation
      福島
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Remarks] 左右の神経の混線を防ぐ“正中線の関所”を守る仕組み

    • URL

      https://www.nig.ac.jp/nig/ja/2017/07/research-highlights_ja/20170726.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 脳全体にセロトニン神経軸索を分散させるしくみ

    • URL

      https://www.nig.ac.jp/nig/ja/2017/12/research-highlights_ja/20171124.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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