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Functional genomics on in vivo fitness of BmNPV

Research Project

Project/Area Number 15K14891
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Insect science
Research InstitutionHokkaido University

Principal Investigator

Hisanori Bando  北海道大学, 農学研究院, 教授 (20189731)

Co-Investigator(Kenkyū-buntansha) 佐藤 昌直  北海道大学, 農学研究院, 助教 (20517693)
Research Collaborator ASANO SHINICHIRO  北海道大学, 大学院農学研究院, 准教授 (60222585)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords昆虫機能利用 / 有用物質生産 / バキュロウイルス
Outline of Final Research Achievements

Bombyx mori nucleopolyhedrovirus (BmNPV) H4 that had genome sharing high sequence similarity (approx. 97%) with that of the type strain of BmNPV T3 showed marked growth advantage in silkworm larvae. Studies using chimeric recombinant BmNPV between H4 and T3 demonstrated that a viral membrane protein gene gp64 as a determinant in the in vivo fitness of BmNPV H4. Further analyses identified amino acid positions involved in the BmNPV H4 phenotype of efficient growth in silkworm larvae. These results suggested the possibility to control growth ability of BmNPV in silkworm larvae by gp64-targetted genome manipulation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] BmNPV膜タンパク質GP64の増殖特性への関与について2015

    • Author(s)
      石川小百合、浅野眞一郎、伴戸久徳
    • Organizer
      日本蚕糸学会第85回大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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