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Identification and analysis of factors involved in acquired immunity system in silkworm

Research Project

Project/Area Number 15K14901
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Insect science
Research InstitutionNational Agriculture and Food Research Organization (2016)
国立研究開発法人農業生物資源研究所 (2015)

Principal Investigator

TANAKA Hiromitsu  国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門 昆虫制御研究領域, ユニット長 (30391577)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords昆虫病理 / 免疫記憶 / カイコ / Dscam遺伝子 / ダウン症細胞接着性分子
Outline of Final Research Achievements

Insects are believed to lack an acquired immune reaction with immunological memory. However, recently we have obtained the data that support the hypothesis that insects also possess an acquired immune reaction with immunological memory. In this study, we analyzed the factors involved in acquired immunity system in silkworm. First, we performed in silico cloning of Down syndrome cell adhesion molecule (Dscam) genes, and found that this gene has 15, and 23 variable isoforms in 4th and 6th exons, respectively. Furthermore, we indicated that expression patterns of these isoforms might be dependent on the kinds of injected bacteria. We further indicated that degree of melanization was decreased by pre-injection of bacteria.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results) (of which Invited: 1 results)

  • [Presentation] 核多角体病ウイルスや細菌に対するカイコの応答性防御機構2016

    • Author(s)
      田中博光
    • Organizer
      第24回病害動物の生理分子生物談話会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] カイコペプチドグリカン認識タンパク質BmPGRP-L6の免疫経路への関与2016

    • Author(s)
      田中博光・勾坂晶
    • Organizer
      平成28年度蚕糸・昆虫機能利用学術講演会 日本蚕糸学会第86回大会
    • Place of Presentation
      京都工芸繊維大学(京都)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Presentation] カイコEts転写因子BmPTDのレボシン遺伝子プロモーターに対する活性制御機構の解析2015

    • Author(s)
      田中博光・勾坂晶
    • Organizer
      平成27年度蚕糸・昆虫機能利用学術講演会日本蚕糸学会第85回大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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