| Project/Area Number |
15K14923
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 医療用タンパク質 / イネ種子 / 胚乳 / プロテインボディ / プロラミン / ドラッグウデリバリー / 形質転換イネ / 植物 / ドラッグデリバリー |
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| Outline of Final Research Achievements |
Our group has analyzed in detail the mechanism by which endogenous prolamin accumulates in the protein body-I (PB-I) existing in rice seed. This is a challenging study aimed at creating new drug delivery system using transgenic rice. In this research, we added new technology to the mechanism, localize medical protein to a specific region of PB-I, drug delivery to intestinal tract of human or domestic animals, so that a small amount of highly effective micro-container for medicine.
From the results of 3 years of research, the promoter sequence of prolamin is important for localizing the medical protein to a specific region of PB-I, and in order to stably accumulate in PB-I, It was revealed that the prolamin coding sequence was necessary. This result is expected to greatly contribute to research and development of oral vaccine rice in the future.
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