Development of bioimaging by near-infrared to visible up-conversion

• Project/Area Number: 15K14938
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Shizuoka University
• Principal Investigator: KAWAI Hideki 静岡大学, 工学部, 准教授 (80324341)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: バイオイメージング / アップコンバージョン / 高分子ミセル / 界面活性剤

Outline of Final Research Achievements

The photophysical properties of up-conversion based on triplet-triplet annihilation using Pd-octaethylporphyrin and diphenylanthracene were investigated in polyethylene-block-poly(ethylene glycol) micelles. The process of up-conversion was occurred in the polymeric micelles containing sensitizer and emitter through the triplet-triplet energy transfer and triplet-triplet annihilation. Upon excitation at 532 nm in deaerated aqueous solutions they showed weak up-conversion fluorescence, the efficiency of which increased dramatically in the presence of surfactant. The threshold power density between the second order and the first order power dependence of up-conversion fluorescence decreased upon addition of surfactant.

Research Products

• [Presentation] 高分子ミセルを用いたアップコンバージョンによるバイオイメージングの開発 (2017)
  • Author(s): 川井秀記, 原田伸治, 早川泰弘
  • Organizer: 平成28年度生体医歯工学共同研究拠点成果報告会
  • Place of Presentation: 東京医科歯科大学、東京都文京区
  • Year and Date: 2017-03-24
• [Presentation] 高分子ミセルでの三重項-三重項消滅に基づくアップコンバージョンの光物性評価 (2017)
  • Author(s): 原田伸治, 川井秀記
  • Organizer: 第97日本化学会春季年会
  • Place of Presentation: 慶應義塾大学・日吉キャンパス、横浜市、神奈川県
  • Year and Date: 2017-03-17
• [Presentation] 高分子ミセルでの三重項-三重項消滅に基づくアップコンバージョンの評価 (2016)
  • Author(s): 原田伸治, 川井秀記
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学・横浜キャンパス、横浜市、神奈川県
  • Year and Date: 2016-09-14
• [Presentation] 疎水化DNAを用いた三重項－三重項消滅によるアップコンバージョン (2016)
  • Author(s): 川井秀記
  • Organizer: 研究会「分子を使った寄せ木細工」
  • Place of Presentation: 島根大学・松江キャンパス、松江市、島根県
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] Evaluation of up-conversion based on triplet-triplet annihilation in polymeric micelles (2016)
  • Author(s): HARADA, Shinji, KAWAI, Hideki
  • Organizer: The 96th CSJ Annual Meeting
  • Place of Presentation: 同志社大学（京都）
  • Year and Date: 2016-03-26