New stem cell therapy base on freeze drying
| Project/Area Number |
15K14944
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Yokohama City University (2016-2017)
Tokyo University of Science (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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|---|
| Keywords | ＤＤＳ / 吸入剤 / 移植 / 再生治療 / ＣＯＰＤ / 難治性肺疾患 / 幹細胞 / ドラッグデリバリーシステム / 吸入製剤 / 肺胞再生治療 / 凍結乾燥 / 移植治療 / 慢性閉塞性肺疾患 |
|---|
| Outline of Final Research Achievements |
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, leading to a widespread and irreversible alveolar collapse.The COPD becomes the third position of the world cause of death. The aim of this study was to identify a treatment target molecule able to regenerate collapsed alveoli. This study is the first one to identify lung stem cells and ECM factor that induce lung repair. The stability of nanoparticles of stem cells and ECM factor significantly increased in comparison with the controls, and pulmonary administration of the nanoparticles regenerated collapsed alveoli. These results suggest that lung stem cells and ECM nanoparticles are effective as novel COPD treatment target compounds.
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Report
(3 results)
Research Products
(38 results)
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[Presentation] 肺胞再生治療薬の開発2015
Author(s)
堀口道子
Organizer
第１４回 肺サーファクタント分子病態研究会
Place of Presentation
北海道(札幌医科大学)
Year and Date
2015-06-06
Related Report
Invited
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[Presentation] 肺胞再生治療薬の開発2015
Author(s)
堀口道子、境仁美、山下親正
Organizer
日本薬剤学会 第３０年会
Place of Presentation
長崎(ブリックホール)
Year and Date
2015-05-21
Related Report
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