| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, leading to a widespread and irreversible alveolar collapse.The COPD becomes the third position of the world cause of death. The aim of this study was to identify a treatment target molecule able to regenerate collapsed alveoli. This study is the first one to identify lung stem cells and ECM factor that induce lung repair. The stability of nanoparticles of stem cells and ECM factor significantly increased in comparison with the controls, and pulmonary administration of the nanoparticles regenerated collapsed alveoli. These results suggest that lung stem cells and ECM nanoparticles are effective as novel COPD treatment target compounds.
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