RNA virus regulation based on symbiotic bacteria

• Project/Area Number: 15K14946
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Kurata Shoichiro 東北大学, 薬学研究科, 教授 (90221944)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 共生細菌 / 抗ウイルス / 抗ウイルス薬

Outline of Final Research Achievements

Recently, the viral diseases mediated by arthropods such as insects become severe problems due to globalization and climate changing. A big clue has been given to this problem from studies of symbiotic bacteria, which is that symbiotic bacteria, Wolbachia, inhibits the replication of RNA viruses in the host insect and induces host resistance against RNA viral infections. In this research, we developed a screening system necessary for the development of antiviral drugs based on the mechanism of virus resistance mediated by symbiotic bacteria.

Research Products

• [Presentation] Study of endosymbiont-induced anti-virus effects in host insects (2016)
  • Author(s): 倉田祥一朗
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-03-23
  • Invited
• [Presentation] ショウジョウバエ培養細胞を用いた細胞内共生細菌Wolbachiaによる宿主ウイルス抵抗性付与機構の解析 (2015)
  • Author(s): 神啓佑、倉石貴透、倉田祥一朗
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Book] DOJIN BIOSCIENCEシリーズ「共生微生物」大野博司編 (2016)
  • Author(s): 矢野環，倉田祥一朗
  • Total Pages: 281
  • Publisher: 化学同人
• [Book] 共生の生物学 (2016)
  • Author(s): 矢野環、倉田祥一朗
  • Publisher: 化学同人
• [Remarks] 東北大学大学院薬学研究科生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html