| Project/Area Number |
15K14950
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CGRP受容体 / CGRP / RAMP1 / 癌 / 免疫制御 / RAPM1 / がん / 樹状細胞 / 神経系 / 免疫系 |
|---|
| Outline of Final Research Achievements |
Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is one of the potent modulators connecting the nervous and immune systems. There are two isoforms of CGRP: α and β. Both CGRP isoforms bind to a specific receptor composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR). CGRP receptors are expressed on immune cells, and CGRP modulates immune responses through its receptor binding. In this study, regulation of tumor formation through the immune system by CGRP was examined. CGRP was found to regulate macrophage functions such as migration and IL-12 production, resulting to suppression of tumor formation. These results indicate the existence of regulation axis of cancer- immune system- nervous system.
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