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Advocacy of cancer microenvironment control axis via immune system by CGRP

Research Project

Project/Area Number 15K14950
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

TSUJIKAWA KAZUTAKE  大阪大学, 薬学研究科, 教授 (10207376)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsCGRP受容体 / CGRP / RAMP1 / 癌 / 免疫制御 / RAPM1 / がん / 樹状細胞 / 神経系 / 免疫系
Outline of Final Research Achievements

Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is one of the potent modulators connecting the nervous and immune systems. There are two isoforms of CGRP: α and β. Both CGRP isoforms bind to a specific receptor composed of receptor activity-modifying protein 1 (RAMP1) and calcitonin receptor-like receptor (CLR). CGRP receptors are expressed on immune cells, and CGRP modulates immune responses through its receptor binding. In this study, regulation of tumor formation through the immune system by CGRP was examined. CGRP was found to regulate macrophage functions such as migration and IL-12 production, resulting to suppression of tumor formation. These results indicate the existence of regulation axis of cancer- immune system- nervous system.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 Other

All Presentation (1 results) Remarks (3 results)

  • [Presentation] CGRPを介した神経-免疫系-癌制御系の検証2017

    • Author(s)
      谷 春佳 野村 加奈子 大川 勝也 上田 裕子 長谷 拓明 深田 宗一朗 辻川 和丈
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Remarks] 神経系による免疫系制御

    • URL

      https://sites.google.com/site/xibaoshengli/home/yan-jiu/gan-mian-yi

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神経系による免疫系の制御

    • URL

      https://sites.google.com/site/xibaoshengli/home/yan-jiu/gan-mian-yi

    • Related Report
      2015 Research-status Report
  • [Remarks] がんの悪性化機構解明と治療標的分子探索

    • URL

      https://sites.google.com/site/xibaoshengli/home/yan-jiu/gan

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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