Unraveling inhibitory effects of NSAIDs on innate immune response
| Project/Area Number |
15K14951
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
SAITOH Tatsuya 徳島大学, 先端酵素学研究所(次世代), 教授 (60456936)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 抗炎症薬 / NSAIDs / 痛風 / 自然免疫 / サイトカイン / オルガネラ |
|---|
| Outline of Final Research Achievements |
NLRP3-inflammasome, an innate immune system, is activated by monosodium urate crystals, and is involved in gout attack. NLRP3-inflammasome is also activated by metabolites such as cholesterol crystals and free fatty acids, and causes the development of lifestyle diseases. Therefore, NLRP3-inflammasome is considered as a target of therapy and drug development of lifestyle diseases. We have examined the effects of non-steroidal anti-inflammatory drugs (NSAIDs), which are used during a gout attack, on NLRP3-inflammasome, and found that they exert their pharmacological effects through different modes of action.
|
Report
(3 results)
Research Products
(24 results)
-
-
-
-
[Journal Article] Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease.2016
Author(s)
Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW, Apte RS
-
Journal Title
Autophagy
Volume: 12
Issue: 10
Pages: 1876-1885
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
[Journal Article] Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.2016
Author(s)
Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL, He YW, Blackman MA, Handley SA, Levine B, Green DR, Reese TA, Artyomov MN, Virgin HW
-
Journal Title
Cell Host Microbe
Volume: 19
Issue: 1
Pages: 91-101
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 日本臨床 増刊号 高尿酸血症・低尿酸血症 Vol.74, No.92016
Author(s)
藤森 新, 山中 寿, 箱田 雅之, 谷口 敦夫, 細山田 真, 髙濵 充寛, 齊藤 達哉, 森崎 隆幸, 森崎 裕子, 久原 とみ子, 安西 尚彦, 大谷 真由, 降幡 知巳, 佐藤 啓造, 藤城 雅也, 李 暁鵬, 勝又 義直, 中村 真希子, 市田 公美, 東 幸仁 他
Total Pages
464
Publisher
日本臨牀社
Related Report
-
-
