| Project/Area Number |
15K14951
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAITOH Tatsuya 徳島大学, 先端酵素学研究所(次世代), 教授 (60456936)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 抗炎症薬 / NSAIDs / 痛風 / 自然免疫 / サイトカイン / オルガネラ |
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| Outline of Final Research Achievements |
NLRP3-inflammasome, an innate immune system, is activated by monosodium urate crystals, and is involved in gout attack. NLRP3-inflammasome is also activated by metabolites such as cholesterol crystals and free fatty acids, and causes the development of lifestyle diseases. Therefore, NLRP3-inflammasome is considered as a target of therapy and drug development of lifestyle diseases. We have examined the effects of non-steroidal anti-inflammatory drugs (NSAIDs), which are used during a gout attack, on NLRP3-inflammasome, and found that they exert their pharmacological effects through different modes of action.
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