| Project/Area Number |
15K14968
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Tohoku University |
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Principal Investigator |
KANNO TARO 東北大学, 歯学研究科, 助教 (30302160)
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| Co-Investigator(Kenkyū-buntansha) |
庭野 吉己 東北大学, 歯学研究科, 教授 (40375184)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | プロアントシアニジン / カテキン / ブドウ種子エキス / 細胞内取込み / 質量分析 |
|---|
| Outline of Final Research Achievements |
To assess if proanthocyanidin (PA), which is consisted of catechin oligomers and has a potential to accelerate cell proliferation in vitro, could accelerate tissue regeneration in vivo, the effect of repeated oral administration of PA on liver regeneration in partially hepatectomized rats was examined. As a result, PA did not accelerate liver regeneration in normal and streptozotocin-induced diabetic rats. Given that bioavailability of oral catechin oligomers is low, I then focused on enterobacterial flora and examined the effect of repeated oral administration of PA on equol-producing bacteria in mice. However, no significant effects were found. I will further make a study on isolated organs.
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