Quality improvement of medicinal plants using insect-plant interaction

• Project/Area Number: 15K14972
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: Ritsumeikan University
• Principal Investigator: Tanaka Ken 立命館大学, 薬学部, 教授 (60418689)
• Research Collaborator: TAKABAYASI Junji ; TAMURA Takayuki ; TATSUO Yoshiaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 化学生態学 / 生薬成分 / 植物昆虫相互作用

Outline of Final Research Achievements

Medicinal plants produce many compounds to help them survive in severe environments. The pharmaceutical properties of many crude drugs are attributable to such secondary metabolites. Therefore, knowledge of the actual function of secondary metabolites triggered in response to environmental factors could be utilized to produce highly functional crude drugs. The present study aims at investigating the prompt response of short period damaged Angelica acutiloba utilizing metabolomic and proteomic analyses. In addition, LC-MS analyses of the larval oral regurgitation of Papilio machaon were performed to identify the natural elicitor.

Research Products

• [Journal Article] Oviposition inhibitor in Umbelliferous medicinal plants for the common yellow swallowtail (Papilio machaon) (2018)
  • Author(s): Morino C., Morita Y., Minami K., Nishidono Y., Nakashima Y., Ozawa R., Takabayashi J., Ono N., Kanaya S., Tamura T., Tezuka Y., Tanaka K.
  • Journal Title: Journal of Natural Medicines Volume: 72 Issue: 1 Pages: 161-165
  • DOI: 10.1007/s11418-017-1124-3
  • Peer Reviewed
• [Journal Article] Metabolomic and Proteomic Analysis of the Response of Angelica acutiloba after Herbivore Attack (2017)
  • Author(s): Kato R., Morita Y., Ina A., Tatsuo Y., Tamura T., Tezuka Y., Tanaka K.
  • Journal Title: Nat. Prod. Comm. Volume: 12 Pages: 1547-1551
  • Peer Reviewed
• [Presentation] 化学生態学的応答を用いたトウキの機能性強化に関する研究 (2018)
  • Author(s): 中原陽平, 南 和輝, 原田将光, 小野直亮, 金谷重彦, 田中 謙
  • Organizer: 日本薬学会第138年会
• [Presentation] キアゲハによる食害を受けたトウキのプロテオーム解析 (2017)
  • Author(s): 加藤梨紗, 伊奈隆年, 田村隆幸, 田中 謙
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2017-03-26
• [Presentation] キアゲハの忌避物質に関する研究 (2017)
  • Author(s): 南 和輝, 阪森宏治, 田 隆幸, 仲島義貴, 西殿悠人, 福井麻琴, 田中陽一郎, 佐藤雅史, 小澤理香, 高林純示, 田中 謙
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2017-03-26
• [Presentation] 薬用植物の化学生態学的応答を用いたトウキの機能性強化に関する研究 (2016)
  • Author(s): 森田侑介、神野拓也、辰尾良秋、田村隆幸、金谷重彦、田中謙
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-28