Investigation of RNA aptamer for polyamine and its application
Project/Area Number |
15K14976
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
|
Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
西村 和洋 千葉大学, 大学院薬学研究院, 准教授 (60302569)
|
Co-Investigator(Renkei-kenkyūsha) |
OGURO Akihiro 東京慈恵会医科大学, 医学部, 講師 (00292508)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 薬学 / 有機化学 / 核酸 / ハイプシン / ポリアミン / スペルミジン / エーテル / 三次元構造 |
Outline of Final Research Achievements |
RNA aptamer is a useful method for drug discovery and RNA aptamer for small molecular compound is a challenging research topic now. To overcome this problem, we performed this research based on “development of novel ether bond formation” and “computational design of conformationally equivalent small molecular compound binding on solid supports ”. As the results, we obtained some expected results. In binding study between small molecular and solid support, it is important to think about functional group, loading amount and size of solid support. In computational study, we succeeded to obtain conformationally equivalent small molecular compound binding on solid supports and we will accomplish their synthesis soon.
|
Report
(3 results)
Research Products
(71 results)
-
[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016
Author(s)
Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
-
Journal Title
Org. Lett.
Volume: 18
Issue: 24
Pages: 6224-6227
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016
Author(s)
Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
-
Journal Title
J. Med. Chem.
Volume: 59
Issue: 15
Pages: 7282-7286
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
Author(s)
Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
-
Journal Title
Adv. Synth. Catal.
Volume: 358
Issue: 15
Pages: 2449-2459
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton- Sensing GPR4 in Extracellular Acidification-Induced Responses2015
Author(s)
Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
-
Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0129334-e0129334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
[Presentation] Palladium Nanoparticle-Catalyzed Carbon(sp<sup>2<sup> and sp<sup>3<sup>)-Hydrogen Bond Functionalizations2016
Author(s)
Takagi, K.; Al-Amin, M.; Hoshiya, N.; Sugimoto, H.; Shiro, Y.; Tobisu, M.; Chatani, N.; Shuto, S.; Arisawa, M.
Organizer
International Symposium on C-O Activation (ISCO-2016)
Place of Presentation
Himeji, Japan
Year and Date
2016-10-25
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Synthetic Study of Laurenidificin2016
Author(s)
Yoshikawa,Y.; Yamakawa, M.; Kobayashi, T.;Arisawa, M.; Fujioka, H.
Organizer
Molecular Chirality Asia 2016
Place of Presentation
Osaka, Japan
Year and Date
2016-04-20
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-