Investigation of RNA aptamer for polyamine and its application

• Project/Area Number: 15K14976
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Osaka University
• Principal Investigator: ARISAWA Mitsuhiro 大阪大学, 薬学研究科, 准教授 (40312962)
• Co-Investigator(Kenkyū-buntansha): 西村 和洋 千葉大学, 大学院薬学研究院, 准教授 (60302569)
• Co-Investigator(Renkei-kenkyūsha): OGURO Akihiro 東京慈恵会医科大学, 医学部, 講師 (00292508)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 薬学 / 有機化学 / 核酸 / ハイプシン / ポリアミン / スペルミジン / エーテル / 三次元構造

Outline of Final Research Achievements

RNA aptamer is a useful method for drug discovery and RNA aptamer for small molecular compound is a challenging research topic now. To overcome this problem, we performed this research based on “development of novel ether bond formation” and “computational design of conformationally equivalent small molecular compound binding on solid supports ”. As the results, we obtained some expected results. In binding study between small molecular and solid support, it is important to think about functional group, loading amount and size of solid support. In computational study, we succeeded to obtain conformationally equivalent small molecular compound binding on solid supports and we will accomplish their synthesis soon.

Research Products

• [Journal Article] Design and synthesis of cyclopropane congeners of resolvin E2, an endogenous proresolving lipid mediator, as its stable equivalents. (2016)
  • Author(s): Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
  • Journal Title: Organic Letters Volume: 18 Pages: 6224-6227
  • DOI: 10.1021/acs.orglett.6b02612
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design, Synthesis, and Identification of 4”α-Azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca2+-mobilizing Second Messenger. (2016)
  • Author(s): Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
  • Journal Title: J. Med. Chem. Volume: 59 Pages: 7282-7286
  • DOI: 10.1021/acs.jmedchem.6b00437
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A. Tanimura, Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate Using a Novel Fluorescent Ligand and Ligand-Binding Domain Combination. (2016)
  • Author(s): Oura, T.; Murata, K.; Morita, T.; Nezu, A.; Arisawa, M.; Shuto, S.; Tanimura, A.
  • Journal Title: Chembiochem, Volume: 17 Pages: 1509-1512
  • DOI: 10.1002/cbic.201600096
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Self-Assembled Multilayer-Stabilized Nickel Nanoparticle Catalyst for Ligand-Free Cross-Coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization (2016)
  • Author(s): Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
  • Journal Title: Adv. Synth. Catal Volume: 358 Pages: 2449-2459
  • DOI: 10.1002/adsc.201600024
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Non-metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes. (2016)
  • Author(s): Tomomi Nada, Yusuke Yoneshige, Yasuhiro Ii, Takashi Matsumoto, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
  • Journal Title: ACS Catl. Volume: 6 Pages: 3168-3171
  • DOI: 10.1021/acscatal.6b00628
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction. (2016)
  • Author(s): Hayato Fukuda, Saki Ito, Kenji Watari, Chihiro Mogi, Mitsuhiro Arisawa, Fumikazu Okajima, Hitoshi Kurose, Satoshi Shuto
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 7 Pages: 493-497
  • DOI: 10.1021/acsmedchemlett.6b00014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of a Sulfur-modified Glass-supported Pd Nanoparticle Catalyst for the Suzuki-Miyaura Coupling (2016)
  • Author(s): Mincen Xiao, Naoyuki Hoshiya, Katsumasa Fujiki, Tetsuo Honma, Yusuke Tamenori, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa
  • Journal Title: Chem. Pharm. Bull.
  • NAID: 130005253911
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Redox Switching of Orthoquinone-Containing Aromatic Compounds using Gas Energy (2016)
  • Author(s): Kazuki Urakawa, Michinori Sumimoto, Mitsuhiro Arisawa, Masaki Matsuda, Hayato Ishikawa
  • Journal Title: Angew. Chem. Int. Ed.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Double carbonylation of aryl iodides with amines under an atmospheric pressure of carbon monoxide using sulfur-modified Au-supported palladium. (2015)
  • Author(s): Nozomi Saito Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato
  • Journal Title: Green Chem Volume: 17 Pages: 2358-2361
  • DOI: 10.1039/c4gc02469a
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst. (2015)
  • Author(s): Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
  • Journal Title: Adv. Synth. Catal Volume: 357 Pages: 2119-2124
  • DOI: 10.1002/adsc.201500055
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Construction of a chiral quaternary carbon center by a radical cyclization/ring-enlargement reaction: synthesis of 4α-azidoethyl carbocyclic ribose, a key unit for the synthesis of cyclic ADP-ribose derivatives of biological importance. (2015)
  • Author(s): Takatoshi Sato, Takayoshi Tsuzuki, Satoshi Takano, Kohtaro Kato, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
  • Journal Title: Tetrahedron Volume: 71 Pages: 5403-5413
  • DOI: 10.1016/j.tet.2015.05.084
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis of 7-Deaza-Cyclic Adenosine-5’-Diphosphate-Carbocyclic-Ribose and its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents. (2015)
  • Author(s): Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
  • Journal Title: J. Org. Chem Volume: 80 Pages: 6619-6627
  • DOI: 10.1021/acs.joc.5b00723
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of Enyne Metathesis/Isomerization/Diels-Alder One-pot Reaction for Novel Near-Infrared (NIR) Dye Core (2015)
  • Author(s): Kohei Yamashita, Yuki Fujii, Shohei Yoshioka, Hiroshi Aoyama, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa
  • Journal Title: Chemistry A European Journal Volume: 23 Pages: 17491-17494
  • DOI: 10.1002/chem.201502313
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] One-pot Olefin Isomerization/ Aliphatic Enamine Ring-closing Metathesis/ Oxidation/ 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a]isoquinolines. (2015)
  • Author(s): Yuki Fujii, Tsunayoshi Takehara, Takeyuki Suzuki, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
  • Journal Title: Advanced Synthesis & Catalysis Volume: 357 Pages: 4055-4062
  • DOI: 10.1002/adsc.201500680
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stereoselective Construction of 2,7-Disubstituted fused-Bis Tetrahydrofuran Skeletons: Biomimetic-Type Synthesis and Biological Evaluation of (±)-and (-)-Aplysiallene and Their Derivatives (2015)
  • Author(s): Maki Yamakawa, Takeshi Kurachi, Yusuke Yoshikawa, Mitsuhiro Arisawa, Yuichiro Okino, Kuniaki Suzuki, and Hiromichi Fujioka
  • Journal Title: Jounal of Organic Chemistry Volume: 80 Pages: 10261-10277
  • DOI: 10.1021/acs.joc.5b01882
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses (2015)
  • Author(s): Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
  • Journal Title: PLoS ONE Volume: 10
  • DOI: 10.1371/journal.pone.0129334
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Development of Highly Efficient Metal Nano-particle Catalyst toward Drug Discovery (2017)
  • Author(s): Arisawa, M.
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
  • Invited
• [Presentation] ピリジン環への位置選択的トリフルオロメチル化反 応の開発 (2017)
  • Author(s): kuboki, Y.; Ohta, R.; Arisawa, M.; Fujhioka, H.
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 鉄ナノ粒子触媒を用いたリガンドフリー熊田カップ リング反応の開発 (2017)
  • Author(s): Akiyama, T.; Taniguchi, T.; Honma, T.; Tamenori, Y.; Sato, Y.; Fujioka, H.; Arisawa, M.
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] ホスホニウム塩中間体を用いた one-pot エーテル環 合成法の開発 (2017)
  • Author(s): Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発 (2017)
  • Author(s): Arisawa, M.
  • Organizer: 明治薬科大学若手研究者講話会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発 (2017)
  • Author(s): Arisawa, M.
  • Organizer: 日本薬学会東海支部特別講演会
  • Place of Presentation: 岐阜
  • Invited
• [Presentation] Aplysiallene の新規合成法の開発とNa+/K+ ATPase 阻害活性研究 (2016)
  • Author(s): Yoshikawa, Y.; Yamakawa, M.; Kobayashi, T.; Suzuki, K.; Okino, Y.; Arisawa, M.; Fujioka, H.
  • Organizer: 第34回メディシナルケミストリーシンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2016-11-30
• [Presentation] (+)-Laurenidificin の全合成と構造決定 (2016)
  • Author(s): Yoshikawa, Y.; Yamakawa, M.; Kobayashi, T.; Arisawa, M.; Fujioka, H.
  • Organizer: 第42回反応と合成の進歩シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2016-11-07
• [Presentation] 芳香族エナミドの 1,6 －エニン環化異性化反応を用いた多置換インドール合成法の開発 (2016)
  • Author(s): Takamoto, K.; Hyogo, N.; Ohno, S.; Fujioka, H.; Arisawa, M.
  • Organizer: 第42回反応と合成の進歩シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2016-11-07
• [Presentation] Palladium Nanoparticle-Catalyzed Carbon(sp＜sup＞2＜sup＞ and sp＜sup＞3＜sup＞)-Hydrogen Bond Functionalizations (2016)
  • Author(s): Takagi, K.; Al-Amin, M.; Hoshiya, N.; Sugimoto, H.; Shiro, Y.; Tobisu, M.; Chatani, N.; Shuto, S.; Arisawa, M.
  • Organizer: International Symposium on C-O Activation (ISCO-2016)
  • Place of Presentation: Himeji, Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] エノン存在下α,β不飽和エステル選択的変換法の開発と環状エーテル合成への応用 (2016)
  • Author(s): Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
  • Organizer: 第46回 複素環化学討論会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-26
• [Presentation] ルテニウムナノ粒子触媒を用いたリガンドフリー鈴木－宮浦反応の開発 (2016)
  • Author(s): Akiyama, T.; Honma, T.; Fujioka, H.; Sato, Y.; Arisawa, M.
  • Organizer: 第46回 複素環化学討論会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-26
• [Presentation] ルテニウムヒドリド触媒を用いたエノールエーテ ルの 1,6-エイン環化異性化反応の開発 (2016)
  • Author(s): Ohno, S.; Takamoto, K.; Fujioka, H.; Arisawa, M.
  • Organizer: 第 63 回 有機金属化学討論会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-14
• [Presentation] ノンメタセシス反応を利用したアザビシクロ[3.1.1]ヘプテンの合成;ルテニウム触媒を用いたアレナ ミドーエンの分子内[2+2]環化付加反応 (2016)
  • Author(s): Ii, Y.; Yoneshige, Y.; Nada, T.; Matsumoto, T.; Fujioka, H.; Shuto, S.; Arisawa, M.
  • Organizer: 第 63 回 有機金属化学討論会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-14
• [Presentation] Synthesis of novel polycyclic nitrogen-containing compounds via ruthenium-catalyzed one-pot metathesis / non-metathesis reaction (2016)
  • Author(s): Fujii, Y.; Yamashita, K.; Yoshioka, S.; Shuto, S.; Fujioka, H.; Arisawa, M.
  • Organizer: 27th International Conference on Organometallic Chemistry (ICOMC 2016)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-07-17
  • Int'l Joint Research
• [Presentation] Nickel-Catalyzed Hydrocarboxylation of Alkynes and Styrenes Using Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst (2016)
  • Author(s): Taniguchi, T.; Saito, N.; Hoshiya, N.; Fujiki, K.; Shuto, S.; Fujioka, H.; Arisawa M.; Sato, Y.
  • Organizer: 27th International Conference on Organometallic Chemistry (ICOMC 2016)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-07-17
  • Int'l Joint Research
• [Presentation] Non-metathesis heterocycle formation by ruthenium-catalyzed intramolecular [2+2] cycloaddition of allenamide-enes to azabicyclo[3.1.1]heptanes (2016)
  • Author(s): Arisawa, M.; Yoneshige, Y.; Nada, T.; Shuto, S.; Fujioka, H.
  • Organizer: 27th International Conference on Organometallic Chemistry (ICOMC 2016)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-07-17
  • Int'l Joint Research
• [Presentation] Ruthenium-Catalyzed 1,6-Enyne Cycloisomerization of Phenyl Enol Ether: Synthesis of 2,3-Disubstituted Benzo[b]furans (2016)
  • Author(s): Ohno, S.; Takamoto, K.; Fujioka, H.; Arisawa, M.
  • Organizer: The 20th International Symposium on Homogeneous Catalysis (ISHC XX)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-07-10
  • Int'l Joint Research
• [Presentation] 硫黄修飾金担持型ニッケル触媒SANiの開発と二酸化炭素固定化反応への利用 (2016)
  • Author(s): Taniguchi, T.; Saito, N.; Hoshiya, N.; Fujiki, K.; Shuto, S.; Fujioka, H.; Arisawa, M.; Sato, Y.
  • Organizer: 第14回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-05-27
• [Presentation] メタセシス/ノンメタセシス連続反応の開発とそれを用いた新規多環式含窒素ヘテロ環化合物の合成及び機能解析 (2016)
  • Author(s): Fujii, Y.; Yamashita, K.; Yoshioka, S.; Fujioka, H.; Shuto, S.; Arisawa, M.
  • Organizer: 第14回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-05-27
• [Presentation] Synthetic Study of Laurenidificin (2016)
  • Author(s): Yoshikawa,Y.; Yamakawa, M.; Kobayashi, T.;Arisawa, M.; Fujioka, H.
  • Organizer: Molecular Chirality Asia 2016
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-04-20
  • Int'l Joint Research
• [Presentation] GABA トランスポーターサブタイプ特異的な新規阻害薬候補化合物の薬理活性 評価 (2016)
  • Author(s): 佐藤 孝行, 井川 ありさ, 圓山 智嘉史, 末政 亮大, 小林 嵩明, 有澤 光弘, 井手 聡一郎, 周東 智, 南 雅文
  • Organizer: 日本薬学会136年会
  • Place of Presentation: 神奈川県、横浜市（パシフィコ横浜）
  • Year and Date: 2016-03-26
• [Presentation] エインメタセシス/Diels-Alder/酸化の 3 連続ワンポット反応を用いた新規含ケイ素 多環式化合物の合成 (2016)
  • Author(s): 吉岡 祥平, 藤居 由基, 藤岡 弘道, 有澤 光弘
  • Organizer: 日本薬学会136年会
  • Place of Presentation: 神奈川県、横浜市（パシフィコ横浜）
  • Year and Date: 2016-03-26
• [Presentation] Microwave とガラス担持型 Pd ナノ粒子触媒を用いたブロモベンゼンの鈴木-宮浦 カップリング反応の開発 (2016)
  • Author(s): 肖 玟岑, 藤岡 弘道, 有澤 光弘
  • Organizer: 日本薬学会136年会
  • Place of Presentation: 神奈川県、横浜市（パシフィコ横浜）
  • Year and Date: 2016-03-26
• [Presentation] 硫黄修飾金担持型ルテニウム触媒を用いたリガンドフリー鈴木-宮浦反応の開発 (2016)
  • Author(s): 秋山 敏毅, 藤岡 弘道, 佐藤 美洋, 有澤 光弘
  • Organizer: 日本薬学会136年会
  • Place of Presentation: 神奈川県、横浜市（パシフィコ横浜）
  • Year and Date: 2016-03-26
• [Presentation] Syntheses of orthoquinone containing aromatic compounds and their redox chromism (2016)
  • Author(s): URAKAWA, Kazuki; SUMIMOTO, Michinori; ARISAWA, Mitsuhiro; MATSUDA, Masaki; ISHIKAWA, Hayato
  • Organizer: 日本化学会第96春季年会2016
  • Place of Presentation: 京都府、京田辺市（同志社大学）
  • Year and Date: 2016-03-24
• [Presentation] Development of Sulfur-Modified Au-Supported Nickel Catalyst (SANi) and Its Application to Catalytic Carboxylation of Multiple Bonds (2016)
  • Author(s): TANIGUCHI, Takahisa; SAITO, Nozomi; HOSHIYA, Naoyuki; FUJIKI, Katsumasa; SHUTO, Satoshi; FUJIOKA, Hiromichi; ARISAWA, Mitsuhiro; SATO, Yoshihiro
  • Organizer: 日本化学会第96春季年会2016
  • Place of Presentation: 京都府、京田辺市（同志社大学）
  • Year and Date: 2016-03-24
• [Presentation] Non-Metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes (2016)
  • Author(s): Arisawa, M.; Yoneshige, Y.; Nada, T.; Ii, Y.; Shuto, S.; Fujioka, H.
  • Organizer: The 20th International Symposium on Homogeneous Catalysis (ISHC XX)
  • Place of Presentation: Kyoto, Japan
  • Int'l Joint Research
• [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発 (2016)
  • Author(s): Arisawa, M.
  • Organizer: 熊本大学大学院自然科学研究科特別講演会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] 硫黄修飾金担持型ルテニウムナノ粒子触媒の開発とリガンドフリー鈴木－宮浦反応への応用 (2016)
  • Author(s): Akiyama, T.; Honma, T.; Fujioka, H.; Sato, Y.; Arisawa, M.
  • Organizer: 第36回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都
• [Presentation] ケトホスホニウム塩形成を利用したエノン存在下でのα，βー不飽和エステルのオレフィン部位選択的変換法の開発 (2016)
  • Author(s): Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
  • Organizer: 第36回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都
• [Presentation] β 位置換様式の異なるエノン間の識別的変換反応の開発とその応用 (2016)
  • Author(s): Morita, K.; Ohta, R.; Watanabe, K.; Aoyama, H.; Arisawa, M.; Fujioka, H.
  • Organizer: 第66回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 高槻
• [Presentation] 置換オキシインドール及び置換 3,4-ジヒドロキノリノンの合成 (2016)
  • Author(s): Miyata, K.; Xiao, M.; Fujioka, H.; Arisawa, M.
  • Organizer: 第66回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 高槻
• [Presentation] 芳香族エナミドを用いる多置換インドール合成法の開発 (2016)
  • Author(s): Takamoto, K.; Hyogo, N.; Ohno, S.; Fujioka, H.; Arisawa, M.
  • Organizer: 第66回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 高槻
• [Presentation] (-)-Aplysiallene およびその誘導体合成とNa+/K+ ATPase 阻害活性研究 (2015)
  • Author(s): 山川真希,吉川祐介,鈴木邦明,沖野雄一郎,有澤光弘, 藤岡弘道
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉県、千葉市（幕張国際 研修センター）
  • Year and Date: 2015-11-25
• [Presentation] A One-Pot Olefin Isomerization / Aliphatic Enamine Ring-Closing Metathesis (RCM) / Oxidation / 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a] isoquinolines (2015)
  • Author(s): Yuki Fujii, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
  • Organizer: 第13回 国際有機化学京都会議： IKCOC-13
  • Place of Presentation: 京都府、京都市（リーガロイヤルホテル京都）
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] Pd(II)-Catalyzed Directing Group-Mediated Arylation and Alkylation of Tertiary C(sp3)-H Bond on Chiral Cyclopropanes (2015)
  • Author(s): Naoyuki Hoshiya, Kei Takenaka, Mitsuhiro Arisawa, Satoshi Shuto, Jun’ichi Uenishi
  • Organizer: 第13回 国際有機化学京都会議： IKCOC-13
  • Place of Presentation: 京都府、京都市（リーガロイヤルホテル京都）
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst (SANi)-Catalyzed Hydrocarboxylation of Alkynes (2015)
  • Author(s): Takahisa Taniguchi, Nozomi Saito, Naoyuki Hoshiya, Katsumasa Fujiki, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa, Yoshihiro Sato
  • Organizer: 第13回 国際有機化学京都会議： IKCOC-13
  • Place of Presentation: 京都府、京都市（リーガロイヤルホテル京都）
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] Ru-Catalyzed 1,6-Enyne Cycloisomerization of Aromatic Enamide, New Strategy toward 2,3-Disubstituted Indole (2015)
  • Author(s): Kohei Takamoto, Norimichi Hyogo, Hiromichi Fujioka, Mitsuhiro Arisawa
  • Organizer: 第13回 国際有機化学京都会議： IKCOC-13
  • Place of Presentation: 京都府、京都市（リーガロイヤルホテル京都）
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] 1,6-エイン環化異性化反応を用いた2,3-二置換インドール合成法の開発 (2015)
  • Author(s): 高本康平、兵後訓道、大野祥平、藤岡弘道、有澤光弘
  • Organizer: 第108回有機合成シンポジウム
  • Place of Presentation: 東京都、新宿区（早稲田大学）
  • Year and Date: 2015-11-05
• [Presentation] エインメタセシス/異性化/Diels-Alder ワンポット反応を用いた新規含窒素多環式化合物の合成とその機能解析 (2015)
  • Author(s): 山下航平，藤居由基，吉岡祥平，藤岡弘道，有澤光弘
  • Organizer: 第41回 反応と合成の進歩シンポジウム
  • Place of Presentation: 大阪府、東大阪市（近畿大学）
  • Year and Date: 2015-10-26
• [Presentation] 生体内ポリアミン標的RNA アプタマーの取得に向けたハイプシン誘導体の合成 (2015)
  • Author(s): 太田礼伊也，阿部敬介，小黒明広，西村和洋，有澤光弘，藤岡弘道
  • Organizer: 第41回 反応と合成の進歩シンポジウム
  • Place of Presentation: 大阪府、東大阪市（近畿大学）
  • Year and Date: 2015-10-26
• [Presentation] エノールエーテルの 1,6-エイン環化異性化反応の開発 ―2,3-二置換ベンゾフランの新規合成法― (2015)
  • Author(s): 大野祥平、高本康平、藤岡弘道、有澤光弘
  • Organizer: 第65回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 大阪府、富田林市（大阪大谷大学）
  • Year and Date: 2015-10-17
• [Presentation] Grubbs 触媒を用いた N-アレニル-o-ビニルアニリン誘導体の分子内[2+2]環化反応 新規含窒素複素環骨格アザビシクロ[3.1.1]ヘプタン骨格の構築とその化学変換 (2015)
  • Author(s): 米重勇祐、名田智美、周東智、藤岡弘道、有澤光弘
  • Organizer: 第65回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 大阪府、富田林市（大阪大谷大学）
  • Year and Date: 2015-10-17
• [Presentation] ルテニウムヒドリドを用いた複素環化合物の合成 (2015)
  • Author(s): 有澤光弘、高本康平、大野祥平、兵後訓道、藤岡弘道
  • Organizer: 平成27年度有機合成化学北陸セミナー
  • Place of Presentation: 富山県、富山市（富山観光ホテル）
  • Year and Date: 2015-10-02
• [Presentation] 硫黄修飾された金担持型ニッケルナノパーティク ルの開発とその有機合成への応用 (2015)
  • Author(s): 星谷 尚亨・藤 木 勝将・谷口 敬寿・周東 智・藤岡 弘道・齋藤 望・ 佐藤 美洋・有澤 光弘
  • Organizer: 第 62 回 有機金属化学討論会
  • Place of Presentation: 大阪府、吹田市（関西大学）
  • Year and Date: 2015-09-07
• [Presentation] 新規オレフィン異性化/エナミン閉環メタセシス (RCM)/1,3-双極子付加環化ワンポット反応の開発とそ れを用いたイソインドロ[1,2-a]イソキノリンの合成 (2015)
  • Author(s): 藤居 由基・嵩原 綱吉・鈴木 健之・藤岡 弘道・周東 智・有澤 光弘
  • Organizer: 第 62 回 有機金属化学討論会
  • Place of Presentation: 大阪府、吹田市（関西大学）
  • Year and Date: 2015-09-07
• [Presentation] 1,6-Cycloisomerization to give 2,3-disubstituted indole catalyzed by ruthenium hydride with N-heterocyclic carbene ligand (2015)
  • Author(s): Kohei, Takamoto, Norimichi Hyogo, Hiromichi Fujioka, Mitsuhiro Arisawa
  • Organizer: 第250回 アメリカ化学会ACS National Meeting & Exposition
  • Place of Presentation: アメリカ合衆国、ボストン
  • Year and Date: 2015-08-16
  • Int'l Joint Research
• [Presentation] Development of One-pot Ring-closing(RCM)/ 1,3-Dipolar Reaction Using Ruthenium Carbene Catalysts and Its Application to the Synthesis of Novel Polycyclic Heterocycle (2015)
  • Author(s): Yuki Fujii, Hiromichi Fujioka, Satoshi Shuto, and Mitsuhiro Arisawa
  • Organizer: 21st International Symposium on Olefin Metathesis and Related Chemistry (ISOM XXI)
  • Place of Presentation: オーストリア、グラーツ
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Development of enyne metathesis / isomerization / Diels-Alder one-pot reaction for novel NIR dye (2015)
  • Author(s): Kohei Yamashita, Hiroshi Aoyama, Hiromichi Fujioka, and Mitsuhiro Arisawa
  • Organizer: 21st International Symposium on Olefin Metathesis and Related Chemistry (ISOM XXI)
  • Place of Presentation: オーストリア、グラーツ
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Nickel-Catalyzed Carboxylation of Alkynes Using Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst (SANi) (2015)
  • Author(s): Takahisa Taniguchi, Nozomi Saito, Naoyuki Hoshiya, Katsumasa Fujiki, Satoshi Shuto, Tetsuo Honma, Hiromichi Fujioka, Mitsuhiro Arisawa and Yoshihiro Sato
  • Organizer: 18th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 18)
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2015-06-28
  • Int'l Joint Research
• [Book] ヘテロ環の化学: 基礎と応用 (2016)
  • Author(s): Nakagawa, M.; Arisawa, M.
  • Total Pages: 256
  • Publisher: 東京化学同人
• [Book] ヘテロ環の化学: 基礎と応用 (2016)
  • Author(s): 中川昌子、有澤光弘
  • Total Pages: 256
  • Publisher: 東京化学同人
• [Remarks] 大阪大学大学院薬学研究科 分子合成化学分野
  • URL: http://gosei.sakura.ne.jp/gosei/
• [Patent(Industrial Property Rights)] Composite containing catalytic metal nanoparticles, and use for same (2016)
  • Inventor(s): Arisawa,M.;Shuto,S.;Hoshiya,N.
  • Industrial Property Rights Holder: Arisawa,M.;Shuto,S.;Hoshiya,N.
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-06-09
  • Application Year: 2016
  • Acquisition Date: 2016-12-22
  • Acquisition Year: 2016