| Project/Area Number |
15K14981
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Shinae 東京工業大学, 生命理工学院, 教授 (40314182)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機ビスマス / 光増感剤 / イメージング / ビスマス / 光線力学療法 |
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| Outline of Final Research Achievements |
The aim of this project is to develop a novel molecular platform for an activatable photosensitizer of which fluorescence and photosensitizing activity are enhanced as desired by exploiting a unique property of organobismuth compounds. The final goal of this project is to establish a novel photodynamic diagnosis and therapeutic method with the activatable photosensitizers. In detail, we aimed to develop bismuth-fused fluorophore with prodrug function targeting to tumor-specific enzymes and to establish an image-guided therapeutic method by the Bi-containing photosensitizers.
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