| Project/Area Number |
15K14982
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Suzuki Takayoshi 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90372838)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 遺伝性疾患 / エピジェネティクス / 脱メチル化酵素 / 脱アセチル化酵素 / 阻害剤 / 活性化剤 / メチル化 / 酵素 / 阻害薬 |
|---|
| Outline of Final Research Achievements |
In this study, aiming to find therapeutic agents for hereditary diseases such as beta-globin disorder and Cornelia de Lange syndrome, we attempted to identify lysine-specific demethylase 1 (LSD1) inhibitors and histone deacetylase 8 (HDAC8) activators. Rational drug design and screening allowed us to identify highly selective and potent LSD1 inhibitors and HDAC8 activators.
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