Development of cancer cell-selective necrosis-inducing agents for cancer treatment
| Project/Area Number |
15K14983
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村田 和義 生理学研究所, 脳機能計測・支援センター, 准教授 (20311201)
牧瀬 正樹 崇城大学, 薬学部, 准教授 (80433001)
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| Research Collaborator |
ARAP Wadih 米国ニューメキシコ大学, 医学部, 教授
PASQUALINI Renata 米国ニューメキシコ大学, 医学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ネクローシス / ペプチドミメティクス / がん / 細胞死 / 肺がん / 癌 / 細胞膜透過性ペプチド / ペプチドミメティックス / 乳がん |
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| Outline of Final Research Achievements |
To assess therapeutical implications of the necrosis-inducing agents for cancer treatment, we developed a neuropilin-1 (NRP-1)-targeted hybrid peptide, which induces non-apoptotic cell death against lung and breast cancer cells. We determined that the mode of cell death induced with the peptide is similar to necrosis. siRNA knockdown of NRP-1 on A549 cells significantly reduced cytotoxicity of the hybrid peptide. Also, treatment of the hybrid peptide on A549 cells lead to the extracellular release of a necrotic marker protein high mobility group B-1. The peptides will be a useful tool for development of novel concept-based anti-tumor agents such as a necrosis-inducer.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain.2016
Author(s)
Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H.
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Journal Title
Glia
Volume: 64
Issue: 11
Pages: 1938-1961
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens.2015
Author(s)
Karjalainen K, Jaalouk DE, Bueso-Ramos C, Bover L, Sun Y, Kuniyasu A, Driessen WH, Cardo-Vila M, Rietz C, Zurita AJ, O'Brien S, Kantarjian HM, Cortes JE, Calin GA, Koivunen E, Arap W, Pasqualini R.
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Journal Title
Clin. Cancer Res.
Volume: 21(13)
Issue: 13
Pages: 3041-3051
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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