Mechanisms underlying endothelial metallothionein induction based on the strategy of bioorganometallics
| Project/Area Number |
15K14992
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Kaji Toshiyuki 東京理科大学, 薬学部薬学科, 教授 (90204388)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオオルガノメタリクス / メタロチオネイン / 有機-無機ハイブリッド分子 / 誘導 / 血管内皮細胞 / 有機－無機ハイブリッド分子 |
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| Outline of Final Research Achievements |
The present study revealed that induction of metallothionein (MT) isoforms MT-1 and MT-2 of vascular endothelial cells mediated by the MTF-1-MRE pathway and Nrf2-ARE pathway, respectively, using organic-inorganic hybrid molecules. Additionally, it was also revealed that induction of MT-1A and MT-2A is mediated by the ALK5-Smad2/Smad4-Sp1 pathway and ALK5-Smad2-Sp1pathway, respectively. It has been postulated that there is no functional difference between MT-1 and MT-2, however, the present results suggest the functional differentiation between the MT isoforms.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Transcriptional induction of metallothionein by tris(pentafluorophenyl)stibane in cultured bovine aortic endothelial cells2016
Author(s)
Fujie, T., Murakami, M., Yoshida, E., Yasuike, S., Kimura, T., Fujiwara, Y., Yamamoto, C. and Kaji, T.
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Journal Title
International Journal of Molecular Sciences
Volume: 17
Issue: 9
Pages: 1381-1381
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells2016
Author(s)
Fujie T, Segawa Y, Uehara A, Nakamura T, Kimura T, Yoshida E, Yamamoto C, Uchiyama M, Naka H, Kaji T.
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Journal Title
The Journal of Toxicological Sciences
Volume: 41
Issue: 2
Pages: 217-224
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 有機金属化合物の細胞毒性2015
Author(s)
山本 千夏，安池 修之，鍜冶 利幸
Organizer
第42回日本毒性学会学術年会
Place of Presentation
ホテル日航金沢（石川県金沢市）
Year and Date
2015-06-29
Related Report
Invited
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