Investigation of difference in intestinal cholesterol absorption among mouse substrains to find out novel regulators for cholesterol absorption
| Project/Area Number |
15K14996
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 消化管吸収 / コレステロール |
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| Outline of Final Research Achievements |
Intestinal cholesterol absorption is an important process to regulate cholesterol levels in the body. However, molecular mechanisms of cholesterol absorption have not been fully uncovered yet. The aim of this study is to reveal novel regulators of intestinal cholesterol absorption by elucidating mouse substrain difference in efficiency of cholesterol absorption. Since various candidate molecules that might be accounted for the strain difference in cholesterol absorption was found by several proteomics approaches, novel key regulators of intestinal cholesterol absorption would be revealed in the near future.
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Report
(3 results)
Research Products
(22 results)
