| Project/Area Number |
15K15000
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
KATO YUKIO 金沢大学, 薬学系, 教授 (30251440)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Yasuhiko 金沢大学, 医学系, 教授 (20313637)
KITAMURA Masanori 金沢大学, 薬学系, 准教授 (80453835)
NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膜輸送体 / ブドウ糖 / ミトコンドリア / メタボローム / 糖代謝 |
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| Outline of Final Research Achievements |
We have previously established gene knockout mice for the solute carrier membrane transporter which is expressed in ubiquitous organs and mainly accepts organic cations as substrates. Our previous metabolome analyses using both wild-type and knockout mice have suggested possible change in glucose metabolism in the body due to the gene knockout. Identification of the molecular mechanism may lead to clarifying the regulatory mechanism for glucose homeostasis and diabetics. Therefore, the aim of the present study is to clarify the role of thie transporter in glucose metabolism and to identify its endogenous substrates.
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