Development of novel transdermal immunotherapy aimed at curing food allergies
| Project/Area Number |
15K15003
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食物アレルギー / 経皮免疫療法 / 臨床研究 / 親水性ゲルパチ / アレルギー / 経皮免疫 |
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| Outline of Final Research Achievements |
We have developed epicutaneous immunotherapy for food allergy. In preclinical studies using mice, allergen-loaded hydrogel patch (HG) induced the production of allergen-specific IgG antibodies. But production of allergen-specific IgE antibodies was suppressed lower than immunity by injection. We also conducted clinical study on children with severe cow milk allergies. By transcutaneous immunotherapy using HG loaded with concentrated milk protein, we successfully raised the threshold dramatically for half of the children without showing severe side effects such as anaphylactic shock. Currently, the safety and effectiveness of this therapy are examined by double blind method.
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Report
(3 results)
Research Products
(9 results)
