| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD) increases the disease risk of liver dysfunction, apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the role of exosome on molecular clock in organ dysfunction remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of clock gene expressions regulating cytochrome P450 (CYPs) in liver. These disruptive effects of clock genes were reflected by the alteration of molecular clock in exosome.
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