Construction of novel MHC-class II based strategy and evaluation method for drug-induced myopathy.
| Project/Area Number |
15K15009
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Saito Yoshiro 国立医薬品食品衛生研究所, 医薬安全科学部, 部長 (50215571)
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| Co-Investigator(Kenkyū-buntansha) |
児玉 進 岡山大学, 医歯薬学総合研究科, 准教授 (20621460)
中村 亮介 国立医薬品食品衛生研究所, 医薬安全科学部, 室長 (50333357)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 副作用 / 機序 / HLA / ゲノム / 薬剤反応性 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
Drug-induced myopathy, including rhabdomyolysis, is a severe adverse reaction that may result in renal failure and death in severe cases. We found a human leukocyte antigen HLA-DRB1 type that was significantly associated with statin-related myopathy by a genome analysis of Japanese patients who developed drug-induced myopathy. In this study, we confirmed the situation of statins in suspected drugs among the reported rhabdomyolysis cases in Japan and evaluated the interaction between HLA-DRB1 protein and suspected drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果は、HLA-DRB1と医薬品との相互作用の可能性を示唆したものであり、重篤副作用の発現機序の理解に一定の意義があると考えられる。またその過程で行った、医薬品医療機器総合機構に「横紋筋融解症」として報告された数の医薬品別の集計結果は、本副作用の安全対策に貢献しうる情報と考えられる。
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products2017
Author(s)
Watanabe M. Kawai Y, Kitayama M, Akao H, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Tsuchiya T, Nakanishi H, Saito K, Takeuchi M, Kajinami K.
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Journal Title
Journal of Cardiology
Volume: 69
Issue: 6
Pages: 625-631
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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