Three-dimensional analyses of human embryos using phase-contrast X-ray computed tomography
| Project/Area Number |
15K15014
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kyoto University |
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Principal Investigator |
Zhao Langying 京都大学, 医学研究科, 研究員 (90582122)
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| Co-Investigator(Kenkyū-buntansha) |
高桑 徹也 京都大学, 医学研究科, 教授 (40244933)
山田 重人 京都大学, 医学研究科, 教授 (80432384)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKISHIMA Haruyuki 京都大学, 大学院医学研究科, 研究員 (10750820)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 発生学 / 画像解剖学 / 位相Ｘ線ＣＴ / ヒト胚子 / イメージング / 放射光 / 仮入力 |
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| Outline of Final Research Achievements |
Using the new imaging method called phase-contrast X-ray computed tomography, the human embryo specimens called Kyoto Collection were imaged and analyzed with high-resolution, compared with the conventional imaging method such as magnetic resonance microscopy. Using the obtained 3D data, 3D reconstruction and visualization were performed, and the morphogenesis such as branching of respiratory pathway and the positional relationship among the eye, the optic nerve and the chiasma has been analyzed morphometrically.
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Report
(3 results)
Research Products
(93 results)
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[Journal Article] Merging and fractionation of muscle synergy indicate the recovery process in patients with hemiplegia: the first study of patients after subacute stroke.2016
Author(s)
Hashiguchi Y, Ohata K, Kitatani R, Yamakami N, Sakuma K, Osako S, Aga Y, Watanabe A, Yamada S.
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Journal Title
Neural Plasticity,
Volume: 2,016
Pages: 5282957-5282957
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.2016
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K.
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Journal Title
J Hum Gen
Volume: 61(10)
Issue: 10
Pages: 879-884
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 「The first human embryonic research for the development of the nasal septum using geometric morphometrics: A new insight for the sensitive period for the Binder phenotype.」(Poster) Cleft20172017
Author(s)
Katsube M, Yamada S, Uwabe C, Makishima H, Miyazaki R, Yamaguchi Y, Ishiyama H, Yamamoto A, Morimoto N, Ito T, Imai H, Matsuda T, Suzuki S.
Organizer
INTERNATIONAL CLEFT CONGRESS 2017
Place of Presentation
Radisson Blu Resort, Temple Bay, Mahabalipuram（Chennai, India）
Year and Date
2017-02-08
Related Report
Int'l Joint Research
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[Presentation] ヒト発生学と先天異常2016
Author(s)
山田重人
Organizer
第12回北関東遺伝診療フォーラム
Place of Presentation
大宮パレスホテル 埼玉県大宮市
Year and Date
2016-11-28
Related Report
Invited
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[Presentation] The current status of conventional prenatal diagnosis in Japan: A Nationwide survey of obstetrics/gynecology facilities.2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
21st The International Federation of Gynecology and Obstetrics (FIGO)
Place of Presentation
Vancouver, Canada
Year and Date
2015-10-04
Related Report
Int'l Joint Research
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[Presentation] ヒト発生学と発生学研究2015
Author(s)
山田重人
Organizer
第25回遺伝医学セミナー
Place of Presentation
三井ガーデンホテル（千葉中央区）
Year and Date
2015-09-04
Related Report
Invited
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[Presentation] Survey of conventional prenatal diagnosis in Japan - Nationwide study for obstetricians about prenatal diagnosis2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
ISPD 19th International Conference on Prenatal Diagnosis and Therapy
Place of Presentation
Columbia, United States
Year and Date
2015-07-12
Related Report
Int'l Joint Research
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