Cellular plasticity of OCT4 expressing somatic cells
| Project/Area Number |
15K15016
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
KOSAKA MITSUKO 岡山大学, 医歯薬学総合研究科, 助教 (50270476)
|
|---|
| Research Collaborator |
MIZUNO NOBUHIKO 岡山大学, 医学部, 客員研究員 (60462735)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 幹細胞 / 体性組織 / 多分化能 / がん / 体性組織幹細胞 / 可塑性 / 体細胞 |
|---|
| Outline of Final Research Achievements |
Oct4A, a POU-family transcription factor, is an indispensable and the preeminent pluripotency factor. However, whether Oct4 function in somatic tissues remains debated. Here we tried some useful systems to correctly understand somatic OCT4 gene function. Our findings open up the possibility again that OCT4 can be normal tissue stem cells and/or tumor initiating cells marker and could play a pivotal role in somatic tissues. In this study, we identified and characterized OCT4 transcripts and their translation products in human carcinoma cell lines.
|
Report
(3 results)
Research Products
(4 results)
