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Near infrared upconversion optogenetics

Research Project

Project/Area Number 15K15025
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionTohoku University

Principal Investigator

Yawo Hiromu  東北大学, 生命科学研究科, 教授 (00144353)

Co-Investigator(Renkei-kenkyūsha) ISHIZUKA Toru  東北大学, 大学院生命科学研究科, 講師 (10344714)
YUASA Hideya  東京工業大学, 大学院生命理工学研究科, 教授 (90261156)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords光遺伝学 / 近赤外光駆動 / アップコンバージョン / ナノ粒子 / チャネルロドプシン / ニューロン / 脳機能操作 / オプトジェネティクス / 神経科学 / 近赤外光 / 光操作 / アニオンチャネルロドプシン / ナノ科学
Outline of Final Research Achievements

Optogenetics is an innovative neuroscience method to control the neural activity even in a living animal. The near infrared (NIR) light (wavelength, 650-1450 nm) penetrates deeper in tissues than the visible light, and is a candidate signal to the brain from outside of the body. However, there have not been the tools to catch the near infrared signal for optogenetics. The lanthanide nanoparticles (LNPs), composed of rare-earth elements, absorb low-energy NIR light to emit high-energy visible light (up-conversion). We created a hybrid optogenetic system which consists of the donor LNPs and the acceptor ChRs which are highly sensitive to the emission wavelengths of LNPs. When the NIR laser light was applied to nearby LNPs, the membrane potential was depolarized to evoke action potentials. It is suggested that the green luminescent light emitted from UCNPs effectively activated ChRs to generate enough large photocurrent to change neural activities even in the living animal.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (89 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (19 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 13 results,  Acknowledgement Compliant: 7 results) Presentation (59 results) (of which Int'l Joint Research: 15 results,  Invited: 9 results) Book (3 results) Remarks (7 results)

  • [Int'l Joint Research] Johns Hopkins University/National University of Singapore(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.2017

    • Author(s)
      Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y.
    • Journal Title

      Cereb Cortex.

      Volume: 印刷中 Issue: 3 Pages: 1-15

    • DOI

      10.1093/cercor/bhx012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization2017

    • Author(s)
      Alemeh Zamani, Shigeo Sakuragi, Toru Ishizuka, Hiromu Yawo.
    • Journal Title

      Biophysics and Physicobiology

      Volume: 14 Issue: 0 Pages: 13-22

    • DOI

      10.2142/biophysico.14.0_13

    • NAID

      130005303959

    • ISSN
      2189-4779
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.2017

    • Author(s)
      Katow, Hidetaka; Kanaya, Teppei; Ogawa, Tomohisa; Egawa, Ryo; Yawo, Hiromu.
    • Journal Title

      Development Growth and Differentiation

      Volume: 59 Issue: 3 Pages: 115-128

    • DOI

      10.1111/dgd.12346

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The regulatory mechanism of ion permeation through a channelrhodopsin derived from Mesostigma viride (MvChR1)2016

    • Author(s)
      Watanabe S, Ishizuka T, Hososhima S, Zamani A, Hoque MR, Yawo H
    • Journal Title

      Photochemical & Photobiological Sciences

      Volume: 15 Issue: 3 Pages: 365-374

    • DOI

      10.1039/c5pp00290g

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.2016

    • Author(s)
      Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 5 Pages: e0155687-e0155687

    • DOI

      10.1371/journal.pone.0155687

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Position- and quantity-dependent responses in zebrafish turning behavior.2016

    • Author(s)
      Umeda K, Ishizuka T, Yawo H, Shoji W.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 27888-27888

    • DOI

      10.1038/srep27888

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.2016

    • Author(s)
      Lee W, Kim D, Rivnay J, Matsuhisa N, Lonjaret T, Yokota T, Yawo H, Sekino M, Malliaras GG, Someya T.
    • Journal Title

      Adv Mater.

      Volume: 28 Issue: 44 Pages: 9722-9728

    • DOI

      10.1002/adma.201602237

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenergic receptor-mediated modulation of striatal firing patterns.2016

    • Author(s)
      Ohta H, Kohno Y, Arake M, Tamura R, Yukawa S, Sato Y, Morimoto Y, Nishida Y, Yawo H.
    • Journal Title

      Neurosci Res.

      Volume: 112 Pages: 47-56

    • DOI

      10.1016/j.neures.2016.05.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.2016

    • Author(s)
      Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 11 Pages: e0166820-e0166820

    • DOI

      10.1371/journal.pone.0166820

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.2016

    • Author(s)
      Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
    • Journal Title

      Mol Psychiatry.

      Volume: 印刷中 Issue: 2 Pages: 211-221

    • DOI

      10.1038/mp.2016.187

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump2015

    • Author(s)
      H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
    • Journal Title

      Nature

      Volume: 未定 Issue: 7550 Pages: 48-53

    • DOI

      10.1038/nature14322

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chimeras of Channelrhodopsin-1 and -2 from Chlamydomonas reinhardtii Exhibit Distinctive Light-induced Structural Changes from Channelrhodopsin-2.2015

    • Author(s)
      Asumi Inaguma, Hisao Tsukamoto, Hideaki E. Kato, Tetsunari Kimura, Toru Ishizuka, Satomi Oishi, Hiromu Yawo, Osamu Nureki, Yuji Furutani
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 18 Pages: 11623-11634

    • DOI

      10.1074/jbc.m115.642256

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling.2015

    • Author(s)
      Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., Yawo, H., Oka, S. and Gu, J.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 28 Pages: 17566-75

    • DOI

      10.1074/jbc.m114.579938

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.2015

    • Author(s)
      Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: 1-23

    • DOI

      10.1371/journal.pone.0132475

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts2015

    • Author(s)
      Notomi T, Kuno M, Ezura Y, Honma M, Ishizuka T, Ohura K, Yao H and Noda M.
    • Journal Title

      Bone

      Volume: 81 Pages: 306-314

    • DOI

      10.1016/j.bone.2015.07.031

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Near-infrared (NIR) up-conversion optogenetics.2015

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Mohammad R. Hoque, Takayuki Yamashita, Akihiro Yamanaka, Eriko Sugano, Hiroshi Tomita, and Hiromu Yawo
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16533-16533

    • DOI

      10.1038/srep16533

    • NAID

      120007179836

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 生命機能の光エンジニアリング2015

    • Author(s)
      石塚徹、江川遼、梅田桂子、東海林亙、八尾寛
    • Journal Title

      生物物理

      Volume: 55 Pages: 311-316

    • NAID

      130005110040

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「巻頭言」光と生命の融合2015

    • Author(s)
      八尾寛
    • Journal Title

      光学

      Volume: 44 Pages: 415-415

    • Related Report
      2015 Research-status Report
  • [Journal Article] オプトジェネティクス(光遺伝学)の情報革命2015

    • Author(s)
      八尾寛
    • Journal Title

      化学と工業

      Volume: 68 Pages: 1012-1017

    • Related Report
      2015 Research-status Report
  • [Presentation] All-optical analysis of mesoscopic circuit function in the primary somatosensory cortex of mice2017

    • Author(s)
      Kaichi Sugihara, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Upconversion-rhodopsin hybrid system for near-infrared manipulation of neural network2017

    • Author(s)
      Hiromu Yawo, Shoko Hososhima, Hideya Yuasa, Takayuki Yamashita, Akihiro Yamanaka, Toru Ishizuka
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Organelle-optogenetics -Intervention of the intracellular Ca2+ dynamics by light-2017

    • Author(s)
      Hiroyuki Igarashi, Ayaka Yoshikawa, Toshifumi Asano, Ayumu Konno, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Is the pre-post ratio of motor projection dependent on the number of competitors? - a quantitative connectomics study2017

    • Author(s)
      Takahiro Takahashi, Hiromu Yawo
    • Organizer
      The 2017 Japan-NIH joint Symposium
    • Place of Presentation
      仙台
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規トランスジェニックラット3 系統の開発- tdTomato レポーターラット, Flame ラット, ChRFR(C167A)レポーターラット-2017

    • Author(s)
      五十嵐敬幸, 小泉協, 金子涼輔, 池田啓子, 江川遼, 柳川右千夫, 村松慎一, 鬼丸洋, 石塚徹, 八尾寛
    • Organizer
      先端モデル動物支援プラットフォーム平成28年度成果発表会
    • Place of Presentation
      大津
    • Year and Date
      2017-02-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Functional mapping of rat barrel cortex for spatiotemporal optogenetic patterns to whiskers2017

    • Author(s)
      劉越人, 櫻木繁雄, 八尾寛
    • Organizer
      先端モデル動物支援プラットフォーム平成28年度成果発表会
    • Place of Presentation
      大津
    • Year and Date
      2017-02-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Receptive field of a neuron in the rat barrel cortex - optogenetic whisker stimulation with a spatiotemporal pattern.2017

    • Author(s)
      Hiromu Yawo
    • Organizer
      the Nanyang Technological University (NTU) workshop on “Shedding light on the brain: merging neuroscience and photonics”
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大脳皮質局所回路のin vivoオール光機能解析2016

    • Author(s)
      小泉協, 八尾寛
    • Organizer
      生理学研究所研究会「シナプス伝達の細胞分子調節機構」
    • Place of Presentation
      岡崎
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] オプトジェネティクス革命2016

    • Author(s)
      八尾寛
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Spectral characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization2016

    • Author(s)
      Alemeh Zamani, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Upconversion-rhodopsin hybrid system for near-infared optogenetics2016

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Hiromu Yawo
    • Organizer
      17th International Conference on Retinal Proteins
    • Place of Presentation
      Potsdam, Germany
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intervention of the intracellular Ca2+ dynamics by light - light-sensitive myoblasts as in vitro model of sarcomere assembly -2016

    • Author(s)
      Hiroyuki Igarashi, Ayaka Yoshikawa, Toshifumi Asano, Ayumu Konno, Toru Ishizuka, Hiromu Yawo
    • Organizer
      17th International Conference on Retinal Proteins
    • Place of Presentation
      Potsdam, Germany
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小胞体Ca2+ダイナミクスの光操作 - 光感受性C2C12を用いたSarcomere assembly 研究モデル2016

    • Author(s)
      五十嵐敬幸, 吉川彩香, 浅野豪文, 石塚徹, 八尾寛
    • Organizer
      第2回日本筋学会学術集会
    • Place of Presentation
      小平市
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] オルガネラ光操作2016

    • Author(s)
      八尾寛
    • Organizer
      ルミノジェネティクス研究会
    • Place of Presentation
      熱海
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オール光のin vivoメゾスコピック脳機能解析2016

    • Author(s)
      八尾寛
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Up-conversion optogenetic system using near-infrared (NIR) light2016

    • Author(s)
      Hiromu Yawo, Shoko Hososhima, Mohammad Razuanul Hoque, Hideya Yuasa, Takayuki Yamashita, Akihiro Yamanaka, Toru Ishizuka
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optogenetic conditioning of paradigms discrimination in the rat whisker-barreL system2016

    • Author(s)
      Kenta Abe, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Involvement of caspase system in the regulation of axon arborization during early developmental stages of chick ciliary ganglion2016

    • Author(s)
      Hidetaka Katow, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] All-optical approach to study mesoscopic circuitry in the primary somatosensory cortex of mouse2016

    • Author(s)
      Kyo Koizumi,. Masaaki Sato, Junichi Nakai, Masamichi Ohkura, Yasunori Hayashi, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optogenetic silencing of neural activity using a chimeric light-driven Na+-transporter rhodopsin2016

    • Author(s)
      Mohammad Hoque, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Functional mapping of rat barrel cortex for spatiotemporal optogenetic patterns to whisker2016

    • Author(s)
      Yueren Liu, Tomokazu Ohshiro, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optogenetics therapy for restoring locomotion after severe spinal cord injury2016

    • Author(s)
      Kenta Takashima, Naoji Matsuhisa, Akira Shimada, Peter Zalar, Tomoyuki Yokota, Masaki Sekino, Hiromu Yawo, Takao Someya, Hiroshi Onodera
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Low-invasive optogenetical stimulation of neurons using near infra-red light2016

    • Author(s)
      Takayuki Yamashita, Hideya Yuasa, Hiromu Yawo, Akihiro Yamanaka
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] How do axons scramble for targets? - Activity-dependent axonal reorganization in developing chick ciliary ganglion2016

    • Author(s)
      Ryo Egawa, Hiromu Yawo
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 発達期神経回路再編成の定量コネクトミクス解析2016

    • Author(s)
      八尾 寛
    • Organizer
      第3回「適応回路シフト」領域班会議
    • Place of Presentation
      猪苗代町
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 軸索はどのようにして標的を奪い合うのか?:発達期軸索投射再編における神経活動の役割2016

    • Author(s)
      江川 遼
    • Organizer
      第3回「適応回路シフト」領域班会議
    • Place of Presentation
      猪苗代町
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Near-infrared (NIR) controlled optogenetics in zebrafish larva2016

    • Author(s)
      Keiko Umeda, Shoko Hososhima, Toru Ishizuka, Hiromu Yawo, Wataru Shoji
    • Organizer
      発生生物学会第49回大会
    • Place of Presentation
      熊本
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウィスカ―バレル野の感覚入力における時空間パターン弁別2016

    • Author(s)
      阿部健太、八尾 寛
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] All-optical approach to study signal integration in the somatosensory cortex of mouse2016

    • Author(s)
      Koizumi, K., Sato, M., Ohkura, M., Nakai, J., Hayashi, Y., Yawo, H.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Near-infared (NIR) up-conversion optogenetics for neural manipulation2016

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Eriko Sugano, Hiroshi Tomita, Toru Ishizuka, Hiromu Yawo
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Involvement of caspase system in the regulation of axon arborization during early developmental stages of chick ciliary ganglion2016

    • Author(s)
      H. Katow, T. Ishizuka, and H. Yawo
    • Organizer
      Dissecting and Understanding Mechanisms for Functional Shift of Brain Network
    • Place of Presentation
      同志社大学(京都府・京都市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] オプトジェネティクス(光遺伝学)~光による生命機能制御~2016

    • Author(s)
      八尾 寛
    • Organizer
      分子ナノテクノロジー第174委員会 第53回研究会
    • Place of Presentation
      京都大学東京品川オフィス(東京都・港区)
    • Year and Date
      2016-03-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 光と生命の融合2016

    • Author(s)
      八尾寛
    • Organizer
      最先端計測とライフサイエンスの近未来
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経細胞における小胞体Ca2+ダイナミクスの光操作2016

    • Author(s)
      杉原嘉一, 五十嵐敬幸, 石塚徹, 八尾寛
    • Organizer
      第48回東北生理談話会
    • Place of Presentation
      盛岡
    • Related Report
      2016 Annual Research Report
  • [Presentation] 発達期神経回路再編成の定量コネクトミクス解析2016

    • Author(s)
      江川 遼
    • Organizer
      第4回「適応回路シフト」領域班会議
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小胞体Ca2+ダイナミクスの光操作-適応回路シフト研究の新展開2016

    • Author(s)
      五十嵐 敬幸
    • Organizer
      第4回「適応回路シフト」領域班会議
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Near-infrared (NIR) light control of neural activities using up-conversion of lanthanide nanoparticles2015

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Mohammad Razuanul Hoque, Hiromu Yawo
    • Organizer
      第7回光操作研究会国際シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都・文京区)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel transgenic animals for tracing and optogenetics -Flame rats and bistable ChR reporter rats-2015

    • Author(s)
      H. IGARASHI, K. KOIZUMI, R. KANEKO, K. NISHIZAWA, Y. YANAGAWA, S.-I. MURAMATSU, K. KOBAYASHI, T. ISHIZUKA, H. YAWO
    • Organizer
      第7回光操作研究会国際シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都・文京区)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ランタニドナノ粒子アップコンバージョンを利用した近赤外光操作2015

    • Author(s)
      八尾寛
    • Organizer
      生理研研究会「シナプス・神経ネットワークの機能ダイナミクス」
    • Place of Presentation
      生理学研究所(愛知県・岡崎市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] OPTOGENETIC 51LENCING OF NEURONAL ACTIVITY US1NG A LlGHT-DRIVEN SODIUM ION PUMP IN MARINE BACTERIA2015

    • Author(s)
      Toru Ishizuka,Shoko Hososhima, Mohammad Razuanul Hoque, Kazuho Yoshida,Keiichi Inoue,Hideki Kandori,Hiromu Yawo
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] NEAR-INFRARED (NIR) OPTOGENETICS USING UP-CONVERSION OF LANTHANIDE NANOPARTICLES2015

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Toru Ishizuka,Hiromu Yawo
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optogenetic induction of contractile ability in C2C12 myotubes2015

    • Author(s)
      Toshifumi Asano, Toru Ishizuka, Hiromu Yawo
    • Organizer
      8th FAOPS Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discrimination of optogenetic whisker-barrel inputs using channelrhodopsin-2 transgenic rat2015

    • Author(s)
      Kenta Abe, Hiromu Yawo
    • Organizer
      8th FAOPS Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Opt-fMRI imaging of somatosensory cortical activity using transgenic rat which expresses channelrhodopsin-2 in the peripheral mechanoreceptive neurons2015

    • Author(s)
      Yukinobu Yokoyama, Akira Sumiyoshi, Ryuta Kawashima, Hiromu Yawo
    • Organizer
      8th FAOPS Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel transgenic animals for tracing and optogenetics -Flame rats and bistable ChR reporter rats2015

    • Author(s)
      H. IGARASHI, K. KOIZUMI, R. KANEKO, K. NISHIZAWA, Y. YANAGAWA, S.-I. MURAMATSU, K. KOBAYASHI, T. ISHIZUKA, H. YAWO
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] "Multi-Linc" - an optogenetic/electrophysiological method to reveal information flows among multiple brain areas2015

    • Author(s)
      A. SAIKI, Y. SAKAI, R. FUKABORI, S. SOMA, J. YOSHIDA, H. YAWO, K. KOBAYASHI, M. KIMURA, Y. ISOMURA
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光を用いて神経活動に介入する「オプトジェネティクス」2015

    • Author(s)
      八尾寛
    • Organizer
      FAN2015 第25回インテリジェント・システム・シンポジウム
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Optogenetic patterning of neural activity2015

    • Author(s)
      八尾寛
    • Organizer
      2015年光化学討論会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] How do axons scramble for targets? - Quantitative connectomics of axonal reorganization during development2015

    • Author(s)
      Ryo Egawa, Toru lshizuka, Hiromu Yawo
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Near-infrared (NIR) optogenetics using up-conversion of lanthanide nanoparticles2015

    • Author(s)
      Hiromu Yawo, Shoko Hososhima, Kenta Abe, Hideya Yuasa, Eriko Sugano, Hiroshi Tomita, Toru lshizuka
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Optogenetic silencing of neural activity using a light-driven Na+ pump from marine bacteria2015

    • Author(s)
      Mohammad Razuanul Hoque, Shoko Hososhima, Kazuho Yoshida, Toru lshizuka, Keiichi lnoue, Hideki Kandori, Hiromu Yawo
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Discrimination of optogenetic whisker-barrel patterns in transgenic rats expressing channelrhodopusin-22015

    • Author(s)
      Kenta Abe, Toru lshizuka, Hiromu Yawo
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Flame rat - evaluation of a reporter transgenic rat line which conditionally expresses bright red fluorescent protein (tdTomato)2015

    • Author(s)
      Hiroyuki lgarashi, Kyo Koizumi, Ryosuke Kaneko, Keiko lkeda, Hiroshi Onimaru, Yuchio Yanagawa, Shin-lchi Muramatsu, Toru lshizuka, Keiichi lnoue, Hideki Kandori, Hiromu Yawo
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] "Multi-Linc" - a novel optogenetic/electrophysiological method to explore information flows among multiple brain areas2015

    • Author(s)
      Akiko Saiki, Yutaka Sakai, Ryoji Fukabori, Junichi Yoshida, Hiromu Yawo, Kazuto Kobayashi, Minoru Kimura, Yoshikazu lsomura
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] How do axons scramble for targets? - Quantitative connectomics of axonal reorganization during development2015

    • Author(s)
      江川遼、石塚徹、八尾寛
    • Organizer
      Frontiers of Brain Science: Tools & Technologies
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Competition or coexistence? Emergence of uniform arborization pattern during developmental axon reorganization2015

    • Author(s)
      Hiromu Yawo, Satoki Sakai, Ryo Egawa
    • Organizer
      Frontiers of Brain Science: Tools & Technologies
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経損傷後の一次求心性神経Aβ線維を介する疼痛関連行動:光遺伝学的アプローチを用いた神経障害性疼痛の新しい評価法2015

    • Author(s)
      田島諒一(Ryoichi Tashima),古賀啓祐(Keisuke Koga),山本将大(Shota Yamamoto),樋口瞳(Hitomi Higuchi),高露雄太(Yuta Kohro),八尾寛(Hiromu Yawo),井上和秀(Kazuhide Inoue),古江秀昌(Hidemasa Furue),津田誠(Makoto Tsuda)
    • Organizer
      日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール(熊本県・熊本市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] ランタニドナノ粒子アップコンバージョン効果による 近赤外オプトジェネティクス2015

    • Author(s)
      八尾寛、細島頌子、阿部健太、湯浅英哉、 菅野江里子、冨田浩史、石塚徹
    • Organizer
      ナノ学会第13回大会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Research-status Report
  • [Presentation] チャネルロドプシン光電変換の特性と応用2015

    • Author(s)
      八尾寛
    • Organizer
      理研シンポジウム「細胞システムの動態と論理 Ⅶ」
    • Place of Presentation
      理化学研究所(埼玉県・和光市)
    • Year and Date
      2015-04-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications2015

    • Author(s)
      Yawo H, Kandori H, Koizumi A
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] Chaptor 8. General description: Future prospects of optogenetics. “Optogenetics: Light-Sensing Proteins and Their Applications”2015

    • Author(s)
      Yawo, H., Egawa, R., Hososhima, S., Wen, L
    • Total Pages
      409
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] Chaptor 21. Strategies to probe mechanoreception: from mechanical to optogenetic approaches. “Optogenetics: Light-Sensing Proteins and Their Applications”2015

    • Author(s)
      Ji, Z.-G., Ishizuka, T., Yawo, H.
    • Total Pages
      409
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Remarks] 細胞/臓器/個体を自在に光らせる!世界初の赤色蛍光レポーターラット

    • URL

      http://www.tohoku.ac.jp/japanese/2016/05/press20160520-02.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 反射運動に可変性をもたらす神経回路の新たな発見

    • URL

      http://www.tohoku.ac.jp/japanese/2016/06/press20160613-02.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科

    • URL

      http://www.lifesci.tohoku.ac.jp/teacher/t_yawo/

    • Related Report
      2015 Research-status Report
  • [Remarks] 東北大学脳科学センター

    • URL

      http://www.bsc.tohoku.ac.jp/researchers/yao_h/

    • Related Report
      2015 Research-status Report
  • [Remarks] 脳機能解析分野

    • URL

      http://neuro.med.tohoku.ac.jp/japanese/noukinou.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 光で筋肉を再生! ~ALSなどの難病治療に対する新たな技術として期待~

    • URL

      http://www.tohoku.ac.jp/japanese/2015/02/press20150205-01.html

    • Related Report
      2015 Research-status Report
  • [Remarks] レアメタル・ナノ粒子の光で脳細胞を活性化-近赤外光信号によるオン・オフ制御の実現

    • URL

      http://www.tohoku.ac.jp/japanese/2015/11/press20151109-01.html

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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