Research Project
Grant-in-Aid for Challenging Exploratory Research
Optogenetics is an innovative neuroscience method to control the neural activity even in a living animal. The near infrared (NIR) light (wavelength, 650-1450 nm) penetrates deeper in tissues than the visible light, and is a candidate signal to the brain from outside of the body. However, there have not been the tools to catch the near infrared signal for optogenetics. The lanthanide nanoparticles (LNPs), composed of rare-earth elements, absorb low-energy NIR light to emit high-energy visible light (up-conversion). We created a hybrid optogenetic system which consists of the donor LNPs and the acceptor ChRs which are highly sensitive to the emission wavelengths of LNPs. When the NIR laser light was applied to nearby LNPs, the membrane potential was depolarized to evoke action potentials. It is suggested that the green luminescent light emitted from UCNPs effectively activated ChRs to generate enough large photocurrent to change neural activities even in the living animal.
All 2017 2016 2015 Other
All Int'l Joint Research (1 results) Journal Article (19 results) (of which Int'l Joint Research: 6 results, Peer Reviewed: 17 results, Open Access: 13 results, Acknowledgement Compliant: 7 results) Presentation (59 results) (of which Int'l Joint Research: 15 results, Invited: 9 results) Book (3 results) Remarks (7 results)
Cereb Cortex.
Volume: 印刷中 Issue: 3 Pages: 1-15
10.1093/cercor/bhx012
Biophysics and Physicobiology
Volume: 14 Issue: 0 Pages: 13-22
10.2142/biophysico.14.0_13
130005303959
Development Growth and Differentiation
Volume: 59 Issue: 3 Pages: 115-128
10.1111/dgd.12346
Photochemical & Photobiological Sciences
Volume: 15 Issue: 3 Pages: 365-374
10.1039/c5pp00290g
PLoS One.
Volume: 11 Issue: 5 Pages: e0155687-e0155687
10.1371/journal.pone.0155687
Sci Rep.
Volume: 6 Issue: 1 Pages: 27888-27888
10.1038/srep27888
Adv Mater.
Volume: 28 Issue: 44 Pages: 9722-9728
10.1002/adma.201602237
Neurosci Res.
Volume: 112 Pages: 47-56
10.1016/j.neures.2016.05.004
Volume: 11 Issue: 11 Pages: e0166820-e0166820
10.1371/journal.pone.0166820
Mol Psychiatry.
Volume: 印刷中 Issue: 2 Pages: 211-221
10.1038/mp.2016.187
Nature
Volume: 未定 Issue: 7550 Pages: 48-53
10.1038/nature14322
J. Biol. Chem.
Volume: 290 Issue: 18 Pages: 11623-11634
10.1074/jbc.m115.642256
Volume: 290 Issue: 28 Pages: 17566-75
10.1074/jbc.m114.579938
PLoS One
Volume: 10 Issue: 7 Pages: 1-23
10.1371/journal.pone.0132475
Bone
Volume: 81 Pages: 306-314
10.1016/j.bone.2015.07.031
Scientific Reports
Volume: 5 Issue: 1 Pages: 16533-16533
10.1038/srep16533
120007179836
生物物理
Volume: 55 Pages: 311-316
130005110040
光学
Volume: 44 Pages: 415-415
化学と工業
Volume: 68 Pages: 1012-1017
http://www.tohoku.ac.jp/japanese/2016/05/press20160520-02.html
http://www.tohoku.ac.jp/japanese/2016/06/press20160613-02.html
http://www.lifesci.tohoku.ac.jp/teacher/t_yawo/
http://www.bsc.tohoku.ac.jp/researchers/yao_h/
http://neuro.med.tohoku.ac.jp/japanese/noukinou.html
http://www.tohoku.ac.jp/japanese/2015/02/press20150205-01.html
http://www.tohoku.ac.jp/japanese/2015/11/press20151109-01.html