Elucidation of the molecular components and regulatory mechanism of anion channels controlling the cell homeostasis and death
| Project/Area Number |
15K15029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
SAKAI Hideki 富山大学, 大学院医学薬学研究部(薬学), 教授 (60242509)
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| Co-Investigator(Kenkyū-buntansha) |
清水 貴浩 富山大学, 大学院医学薬学研究部(薬学), 准教授 (40353437)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生理学 / 細胞・組織 / イオンチャネル / 生体膜 / 細胞容積 |
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| Outline of Final Research Achievements |
Volume-sensitive outward rectifying (VSOR) anion channel contributes to keep cell homeostasis and to trigger cell death such as apoptosis. In this study, we tried to elucidate the molecular components of the VSOR anion channel by using cellular physiological and molecular physiological techniques.
Here, we found that SSNK-1 (tentative name) is one of essential components of the VSOR channel. SSNK-1 may be associated with LRRC8A in the membrane microdomain of plasma membrane, where they elicit the channel activity for the cell volume regulation. In contrast, SSNK-2 and SSNK-3 were not involved in formation of the VSOR anion channel.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.2015
Author(s)
Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.
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Journal Title
Biochim Biophys Acta.
Volume: 1848
Issue: 10
Pages: 2326-2336
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 胃細胞の分泌膜界面の構成と機能2015
Author(s)
酒井秀紀，藤井拓人，清水貴浩
Organizer
生理研研究会「第3回生体界面研究会」
Place of Presentation
自然科学研究機構 生理学研究所（愛知県岡崎市）
Year and Date
2015-07-16
Related Report
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