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Bond formation through oxytocin by the sexual behavior

Research Project

Project/Area Number 15K15031
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionOkayama University

Principal Investigator

Matsui Hideki  岡山大学, 医歯薬学総合研究科, 教授 (30157234)

Co-Investigator(Kenkyū-buntansha) 松下 博昭  岡山大学, 医歯薬学総合研究科, 助教 (60732394)
Research Collaborator Hein Min Latt  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsオキシトシン / 絆 / ストレス / 社会行動 / コルチコステロン
Outline of Final Research Achievements

Oxytocin (OT), a neuropeptide produced from the paraventricular nucleus and the supraoptic nucleus of the hypothalamus, involves in maternal and social behaviors and male-female pair bonding. OT has been shown to mediate antistress and antidepressant-like effects in mice and rats. Glucocorticoids, corticosterone (CORT) in rodents, are released from adrenal cortex in response to stressful stimuli. Their overexposure in animals has been implicated in dendritic atrophy, apoptosis of hippocampal neurons and hippocampal dysfunction. We found that CORT induced the dendritic atrophy as well as apoptosis in primary cultures of mouse hippocampal neurons, both of which were prevented by co-treatment with OT. We also found that plasma CORT levels were lower in mating male mice compared to non-mating counterparts, and this effect was lost in OTR-KO mice. The findings suggest that there might be interplay between OT and glucocorticoids in stress regulation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Oxytocin inhibits corticosterone-induced apoptosis in primary hippocampal neurons.2018

    • Author(s)
      Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui
    • Journal Title

      Neuroscience

      Volume: - Pages: 383-389

    • DOI

      10.1016/j.neuroscience.2018.03.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] オキシトシンは海馬神経細胞におけるコルチコステロン誘導性の樹状突起の萎縮を抑制する2017

    • Author(s)
      佐藤亜紀、ヘインミンラット、松下博昭、道上宏之、西木禎一、松井秀樹
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Oxytocin prevents corticosterone-induced dendritic atrophy in mouse hippocampal neurons2017

    • Author(s)
      Hein Min Latt, Aki Sato, Yuuri Koga, Hiroaki Matsushita, Hiroyuki Michiue, Atsushi Fujimura, Teiichi Nishiki, Hideki Matsui
    • Organizer
      第69回日本生理学会中国四国地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sildenafil exerts antianxiety-like effect in male mice via oxytocin2017

    • Author(s)
      Hein Min Latt, Hiroaki Matsushita, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Hideki Matsui
    • Organizer
      26th Annual Meeting of the International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuroprotective effect of oxytocin on corticosterone-induced apoptosis in mouse hippocampal neurons2016

    • Author(s)
      Hein Min Latt, Miku Morino, Yuuri Koga, Hiroaki Matsushita, Hiroyuki Michiue, Teiichi Nishiki, Hideki Matsui
    • Organizer
      第68回日本生理学会中国四国地方会
    • Place of Presentation
      岡山大学 鹿田キャンパス Junko Fukutake Hall(岡山市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Antianxiety-like effect of sildenafil via oxytocin signaling pathway2016

    • Author(s)
      Hein Min Latt, Hiroaki Matsushita, Taiki Omatsu, Mitsuhiro Matsuzaki, Hiroyuki Michiue, Teiichi Nishiki, Hideki Matsui
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] オキシトシンはコルチコステロン誘導性アポトーシスから神経細胞を保護する2016

    • Author(s)
      ラットヘインミン、森野未来、佐藤亜紀、松下博昭、道上宏之、西木禎一、松井秀樹
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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