| Project/Area Number |
15K15033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
早川 朋子 琉球大学, 医学(系)研究科(研究院), 助教 (30420821)
岡野 ジェイムス洋尚 東京慈恵会医科大学, 医学部, 教授 (90338020)
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| Co-Investigator(Renkei-kenkyūsha) |
OKANO James Hirotaka 東京慈恵会医科大学, 医学部, 教授 (90338020)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神疾患 / 統合失調症 / 家系 / ゲノム / iPSC / iPS細胞 / ゲノム解析 / iPS / schizophrenia / mood disorder |
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| Outline of Final Research Achievements |
Psychiatric disorders, even with schizophrenia alone, have an incidence of 1% of the population, and there is no curative treatment, which is a social problem. For that reason, large-scale of genome wide association studies and research to elucidate the molecular pathology of the disease have been conducted, but the molecular pathologies of onset are still unknown. We conducted a family survey of psychiatric disorders and found a with large schizophrenia family. In this study, genome analysis and establishment of disease specific iPS cells were carried out in the same family to study the pathology, and we have identified disease related genes.
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