Noninvasive assay development of interstitial fluid pH and bicarbonate concentration by MRI and Raman spectrum

• Project/Area Number: 15K15034
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Marunaka Yoshinori 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00127036)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMOTO KANJI 広島工業大学, 生命学部, 教授 (70111903) ; Giuseppe Pezzotti 京都工芸繊維大学, 大学院工芸科学研究科, 教授 (70262962) ; SEO YOSHITERU 獨協医科大学, 医学部, 教授 (90179317)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 間質液 / pH / 糖尿病 / ラマン分光 / アルツハイマー型認知症 / 核磁気共鳴 / 重炭酸イオン / インスリン / インスリン抵抗性 / 組織間質液

Outline of Final Research Achievements

The diabetes number of patients in 2012 amounts to 20 million in 370 million people, our country in the world, and it is reported that onset of the Alzheimer's dementia is higher in in the type 2 diabetes patient than normal ones. We found that interstitial liquid pH and HCO3- concentration participated in insulin-resistant and amyloid beta synthesis in Alzheimer's dementia. Therefore, the measurement of human brain interstitial fluid pH and HCO3- concentration is important for a preventive medical diagnosis of diabetes and Alzheimer's dementia, but the noninvasive assay of interstitial fluid pH HCO3- concentration in human brain is not yet developed. The purpose of the present study is to develop the noninvasive assay of the interstitial fluid pH and HCO3- concentration using using nuclear magnetic resonance imaging and Raman spectrum.

Research Products

• [Journal Article] Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells (2017)
  • Author(s): Puppulin P, Pezzotti G, Sun H, Hosogi S, Nakahari T, Inui T, Kumamoto Y, Tanaka H, MARUNAKA Y
  • Journal Title: Scientific Reports Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia (2017)
  • Author(s): Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Shimamoto C, Matsumura H, Nakano T, Sano K, Inui T, MARUNAKA Y, Nakahari T
  • Journal Title: Pflugers Archiv - Eur J Physiol Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cytosolic Cl- affects the anticancer activity of paclitaxel in the gastric cancer cell line, MKN28 cell (2017)
  • Author(s): Tanaka S, Miyazaki H, Shiozaki A, Ichikawa D, Otsuji E, MARUNAKA Y
  • Journal Title: Cell Physiol Biochem Volume: 42 Issue: 1 Pages: 68-80
  • DOI: 10.1159/000477116
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Actions of quercetin, a flavonoid, on ion transporters: its physiological roles (2017)
  • Author(s): MARUNAKA Y
  • Journal Title: Annals of the New York Academy of Sciences Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 2 Pages: 197-207
  • DOI: 10.1007/s00535-017-1338-x
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Analysis of aprotinin, a protease inhibitor, action on the trafficking of epithelial Na+ channels (ENaC) in renal epithelial cells using a mathematical model. (2017)
  • Author(s): Sasamoto, K., Marunaka, R. #, Niisato, N., Sun, H., Taruno, A., Pezzotti, G., Yamamoto, T., Kanamura, N., Zhu, W., Nishio, K., Inui, T., Eaton, D.C., & Marunaka, Y.
  • Journal Title: Cell Physiol Biochem Volume: 41 Issue: 5 Pages: 1865-1880
  • DOI: 10.1159/000471934
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5. (2017)
  • Author(s): Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: Int J Oncol Volume: 50 Issue: 5 Pages: 1857-1867
  • DOI: 10.3892/ijo.2017.3940
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regulation of osmolality for cancer treatment. (2017)
  • Author(s): Shiozaki A, Ichikawa D, Kosuga T, Marunaka Y, Otsuji E.
  • Journal Title: J Physiol Sci Volume: 印刷中 Issue: 3 Pages: 353-360
  • DOI: 10.1007/s12576-017-0528-x
  • NAID: 40021176358
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Actions of quercetin, a polyphenol, on blood pressure. (2017)
  • Author(s): Marunaka, Y., Marunaka, R., Sun, H., Yamamoto, T., Kanamura, N., Inui, T. & Taruno, A.
  • Journal Title: Molecules Volume: 22 Issue: 2 Pages: 209-209
  • DOI: 10.3390/molecules22020209
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells. (2017)
  • Author(s): Taruno, A. & Marunaka, Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 482 Issue: 2 Pages: 331-335
  • DOI: 10.1016/j.bbrc.2017.01.118
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma (2017)
  • Author(s): Ariyoshi Y, Shiozaki A, Ichikawa D, Shimizu H, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, MARUNAKA Y, Otsuji E
  • Journal Title: Oncotarget Volume: 8 Pages: 2209-2223
  • Peer Reviewed
• [Journal Article] Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala (2017)
  • Author(s): Yoshimoto K, Nagao M, Watanabe Y, Yamaguchi T, Ueda S, Kitamura Y, Nishimura K, Inden M, MARUNAKA Y, Hattori H, Murakami K, Tokaji M, Ochi K
  • Journal Title: Pharmacol Biochem Behavior Volume: 153 Pages: 1-11
  • DOI: 10.1016/j.pbb.2016.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma. (2017)
  • Author(s): Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Oncotarget Volume: 8 Issue: 11 Pages: 17921-17935
  • DOI: 10.18632/oncotarget.14900
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adeno-Associated Virus-Mediated Gene Transferinto Taste Cells In Vivo (2017)
  • Author(s): Taruno A, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y
  • Journal Title: Chemical Senses Volume: 42 Pages: 69-78
  • DOI: 10.1093/chemse/bjw101
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vibrational monitor of early demineralization in tooth enamel after in vitro exposure to phosphoridic liquid (2017)
  • Author(s): Pezzotti G, Adachi T, Gasparutti I, Vincini G, Zhu W, Boffelli M, Rondinella A, Marin E, Ichioka H, Yamamoto T, MARUNAKA Y, Kanamura N
  • Journal Title: Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy Volume: 173 Pages: 19-33
  • DOI: 10.1016/j.saa.2016.08.036
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intracellular chloride ion concentration in differentiating neuronal cell and its role in growing neurite. (2016)
  • Author(s): Nakajima K, Marunaka Y
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 479 Issue: 2 Pages: 338-342
  • DOI: 10.1016/j.bbrc.2016.09.075
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In Situ Spectroscopic Screening of Osteosarcoma Living Cells on Stoichiometry-Modulated Silicon Nitride Bioceramic Surfaces (2016)
  • Author(s): G. Pezzotti, B.J. McEntire, R. Bock, W. Zhu, F. Boschetto, A. Rondinella, E. Marin, Y. Marunaka, T. Adachi, T. Yamamoto, N. Kanamura, B.S. Bal
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 2(7) Issue: 7 Pages: 1121-1134
  • DOI: 10.1021/acsbiomaterials.6b00126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax. (2016)
  • Author(s): Marunaka, Y., Marunaka, R., Sun, H., Yamamoto, T., Kanamura, N. & Taruno, A..
  • Journal Title: Ann Transl Med. Volume: 4 Issue: S1 Pages: S11-S11
  • DOI: 10.21037/atm.2016.10.42
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport. (2016)
  • Author(s): Marunaka, Y., Niisato, N., Miyazaki, H., Nakajima, K., Taruno, A., Sun, H., Marunaka, R., Okui., M., Yamamoto, T., Kanamura, N., Kogiso, H., Ikeuchi, Y., Kashio, M., Hosogi, S. & Nakahari, T.
  • Journal Title: Curr Med Chem. Volume: 23 Issue: 37 Pages: 1-12
  • DOI: 10.2174/0929867323666160919095043
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma. (2016)
  • Author(s): Kudou M, Shiozaki A, Kosuga T, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Hosogi S, Nakahari T, Marunaka Y, Otsuji E.
  • Journal Title: J Cancer Volume: 7 Issue: 11 Pages: 1524-1533
  • DOI: 10.7150/jca.15181
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Validation of a protocol based on Raman and Infrared spectroscopies to nondestructively estimate the oxidative degradation of UHMWPE used in total joint arthroplasty (2016)
  • Author(s): Puppulin L, Miura Y, Casagrande E, Hasegawa M, MARUNAKA Y, Tone S, Sudo A, Pezzotti G
  • Journal Title: Acta Biomaterialia Volume: 38 Pages: 167-178
  • DOI: 10.1016/j.actbio.2016.04.040
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] <b>PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca</b>^<b>2+</b><b>-regulated </b><b>exocytosis </b> (2016)
  • Author(s): Tanaka S, Hosogi S, Sawabe Y, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
  • Journal Title: Biomedical Research Volume: 37 Issue: 3 Pages: 167-178
  • DOI: 10.2220/biomedres.37.167
  • NAID: 130005161059
  • ISSN: 0388-6107, 1880-313X
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sodium-chloride Difference and Metabolic Syndrome: A Population-based Large-scale Cohort Study (2016)
  • Author(s): Kimura T, Hashimoto Y, Tanaka M, Asano M, Yamazaki M, Oda Y, Toda H, MARUNAKA Y, Nakamura N, Fukui M
  • Journal Title: Internal Medicine Volume: 55 Issue: 21 Pages: 3085-3090
  • DOI: 10.2169/internalmedicine.55.7000
  • NAID: 130005276939
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Silicon Nitride Bioceramics Induce Chemically Driven Lysis in Porphyromonas Gingivalis. (2016)
  • Author(s): Pezzotti G, Bock RM, McEntire BJ, Jones E, Boffelli M, Zhu W, Baggio G, Boschetto F, Puppulin L, Adachi T, Yamamoto T, Kanamura N, Marunaka Y, Bal BS
  • Journal Title: Langmuir Volume: 32 Issue: 12 Pages: 3024-035
  • DOI: 10.1021/acs.langmuir.6b00393
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice. (2016)
  • Author(s): Tsuji T, Matsuo K, Nakahari T, Marunaka Y, Yokoyama T.
  • Journal Title: Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice. Volume: 73 Issue: 1 Pages: 45-56
  • DOI: 10.1002/cm.21264
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PPARα activation of NOS1 via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in enhancement of Ca2+-regulated exocytosis (2016)
  • Author(s): Tanaka S, Hosogi S, Sawabe Y, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
  • Journal Title: Biomedical Research Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter. (2015)
  • Author(s): Sasamoto K, Niisato N, Taruno A, Marunaka Y.
  • Journal Title: Front Physiol Volume: 6 Pages: 370-370
  • DOI: 10.3389/fphys.2015.00370
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effect of pH and monovalent cations on the Raman spectrum of water: Basics revisited and application to measure concentration gradients at water/solid interface in Si3N4 biomaterial (2015)
  • Author(s): Pezzotti G, Puppulin L, La Rosa A, Boffelli M, Zhu W, McEntire BJ, Hosogi S, Nakahari T, MARUNAKA Y
  • Journal Title: Chemical Physics Volume: 463 Pages: 120-136
  • DOI: 10.1016/j.chemphys.2015.10.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Carbonic anhydrase XII as an independent prognostic factor in advanced esophageal squamous cell carcinoma. (2015)
  • Author(s): Ochi F, Shiozaki A, Ichikawa D, Fujiwara H, Nakashima S, Takemoto K, Kosuga T, Konishi H, Komatsu S, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
  • Journal Title: Journal of Cancer Volume: 6 Issue: 10 Pages: 922-929
  • DOI: 10.7150/jca.11269
  • Peer Reviewed / Open Access
• [Journal Article] Raman spectroscopy of human skin: looking for a quantitative algorithm to reliably estimate human age (2015)
  • Author(s): Pezzotti G, Boffelli M, Miyamori D, Uemura T, MARUNAKA Y, Zhu W, Ikegaya H
  • Journal Title: J Biomed Optics Volume: 20 Issue: 6 Pages: 65008-65008
  • DOI: 10.1117/1.jbo.20.6.065008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of Brazilian green propolis in patients with type 2 diabetes: A double blind randomized placebo-controlled study (2015)
  • Author(s): Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N, MARUNAKA Y
  • Journal Title: Biomedical Reports Volume: 3 Pages: 355-360
  • Peer Reviewed / Open Access
• [Journal Article] Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: I, Theoretical foundations (2015)
  • Author(s): Pezzotti G, Zhu W, Boffelli M, AdachiT, Ichioka H, Yamamoto T, MARUNAKA Y, Kanamura N
  • Journal Title: Analytical and Bioanalytical Chemistry Volume: 407( Issue: 12 Pages: 3325-3342
  • DOI: 10.1007/s00216-015-8472-1
  • Peer Reviewed
• [Journal Article] Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function (2015)
  • Author(s): MARUNAKA Y
  • Journal Title: World J Diabetes Volume: 6:125-135
  • Peer Reviewed / Open Access
• [Journal Article] Membrane Transport: Ionic Environments, Signal Transduction, and Development of Therapeutic Targets (2015)
  • Author(s): Tomoda A, MARUNAKA Y, Eaton DC, Dinudom A
  • Journal Title: Biomed Res Int Volume: 2015 Pages: 581626-581626
  • DOI: 10.1155/2015/581626
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sodium-chloride Difference and Metabolic Syndrome: A Population-based Large-scale Cohort Study
  • Author(s): Kimura T, Hashimoto Y, Tanaka M, Asano M, Yamazaki M, Oda Y, Toda H, Marunaka Y, Nakamura N, Fukui M
  • Journal Title: International Medicine Volume: 印刷中
  • NAID: 130005276939
• [Presentation] Regulation of body environments by epithelial ion transport (2017)
  • Author(s): MARUNAKA Y
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: 浜松
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] Neurotransmission of taste mediated by calcium homeostasis modulator ion channels (2017)
  • Author(s): Taruno A, MARUNAKA Y
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: 浜松
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] Insulin and the CFTR Chloride Channel. (2016)
  • Author(s): MARUNAKA Y, Niisato N, Hongxin Sun, Inui T.
  • Organizer: The 30th Annual North American Cystic Fibrosis Conference.
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2016-10-27
  • Int'l Joint Research / Invited
• [Presentation] How do chloride and hydrogen ions regulate body function? (2016)
  • Author(s): MARUNAKA Y
  • Organizer: 2016 International Conference of Physiological Science
  • Place of Presentation: Beijing, China
  • Year and Date: 2016-09-25
  • Int'l Joint Research / Invited
• [Presentation] Homologous CALHM subunits assemble to form a novel voltage-gated ATP channel (2016)
  • Author(s): Taruno A, Miyazaki H, Niisato N, Hongxin S, Kashio M, MARUNAKA Y.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] ブラジル産プロポリスの糖尿病に対する効果 (2016)
  • Author(s): 丸中良典
  • Organizer: 第16回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-10
  • Invited
• [Presentation] Purinergic neurotransmission of taste by CALHM channel (2016)
  • Author(s): Taruno A, MARUNAKA Y.
  • Organizer: 17th ISOT JASTS 50th Annual Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Presentation] Cl- and H+ as mediators of biofunction and biodysfunction in health and disease (2016)
  • Author(s): Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] New method based on Raman spectroscopy to detect in-situ concentrations of HCO3-, Na+ and K+ from physiological relevant solutions. Symposium on “Frontiers in non-invasive, non-labeled methodology for detecting cellular function and environments” (2016)
  • Author(s): Puppulin L, Pezzotti G, Hosogi S, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] The role of Raman spectroscopy in preventive medicine (2016)
  • Author(s): Pezzotti G, Ikegaya H, Miyamori D, Yamamoto T, Kanamura N, Adachi T, Sugano N, Zhu W, Takahashi Y, Yamamoto K, Puppulin L, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] CALHM1 and CALHM3 are assembled to form a novel voltage-gated ATP channel (2016)
  • Author(s): Taruno A, Miyazaki H, Niisato N, Sun H, Kashi M, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] Analyses of subcellular localization of CALHM1 channel (2016)
  • Author(s): Kashio M, Taruno A, Sun Hongxin, Kobayashi K, Sano H, Ohsaki Y, Kido M, Nambu A, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Activation of ciliary beating by carbocistein via modulation of [Cl-]i and pHi in bronchiolar ciliary cells in mic (2016)
  • Author(s): Ikeuch Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Ciliary beat frequency modulated by PDE1A activity in procaterol stimulated mouse bronchiole (2016)
  • Author(s): Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Shimamoto C, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Effect of IL-13 on the ciliary beating of nasal epithelium of mice (2016)
  • Author(s): Kuremoto T, Murakami K, Hosogi S, Yasuda M, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Activation of ciliary beating by Seihai-to in distal airway epithelial cells of mice (2016)
  • Author(s): Sumiya S, Hosogi S, Ikeuchi Y, Kogiso H, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Simulation of Cl- secretion in epithelial tissues: New methodology estimating activity of electroneutral Cl- transporter (2016)
  • Author(s): Sasamoto K, Niisato N, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] A regulatory mechanism for apical surface expression of ENaC through the ubiquitin-proteasome pathway in renal epithelial A6 cells (2016)
  • Author(s): Niisato N, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] KCNJ15/Kir4.2 and intracellular polyamines ouples to sense weak extracellular electric field in electrotaxis (2016)
  • Author(s): Nakajima K, Marunaka Y, Zhao M
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] PPARα-stimulated NOS1 phosphorylation mediated via PI3K/Akt in antral mucous cells: enhancement of Ca2+-regulated exocytosis (2016)
  • Author(s): Tanaka S, Hosogi S, Shimamoto C, Matsumura H, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] Ambroxol-stimulated increase in CBA and CBF via pHi increase and [Cl-] decrease in airway ciliary (2016)
  • Author(s): Hosogi S, Kogiso H, Ikeuchi Y, Nakahari T, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] The molecular mechanism of intracellular Cl- in cancer progression by regulating Src kinase signal cascade (2016)
  • Author(s): Miyazaki H, Ue T, Tanaka S, Nakayama Y, Marunaka Y
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo, Hokaido
  • Year and Date: 2016-03-22
• [Presentation] How are Cl- and H+ involved in diseases such as hypertension, diabetes and cancer? (2016)
  • Author(s): MARUNAKA Y
  • Organizer: International Symposium on Ion Channels, Transporters and Signal Transduction
  • Place of Presentation: 京都
  • Int'l Joint Research / Invited
• [Presentation] Roles of lipid raft in epithelial Na+ channel (ENaC) function. Symposium on “New insights into integral regulators of the epithelial ion transport in health and disease (2015)
  • Author(s): Marunaka Y, Niisato N
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited
• [Presentation] Enhancement of ciliary beating by Carbocystein via modulation of [Cl-]i and pHi in bronchiolar ciliary cells in mice (2015)
  • Author(s): Nakahari T, Ikeyuchi Y, Kogiso H, Tanaka S, Hosogi S, Marunaka Y
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Ambroxol activated respiratory mucociliary transport via pHi increase and [Cl-]i decrease in mice (2015)
  • Author(s): Hosogi S, Nakahari T, Marunaka Y
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Procaterol stimulated ciliary beat frequency modulated via PDE1 in mouse bronchiolar cilia (2015)
  • Author(s): Kogiso H, Ikeuchi Y, Tanaka S, Shimamoto C, Nakahari T, Marunaka Y
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] PPARα modulation mediated via PI3K/Akt pathway of Ca2+-regulated exocytosis in antra mucous cells (2015)
  • Author(s): Tanaka S, Shimamoto C, Matsumura H, Nakahari T, Marunaka Y
  • Organizer: 8th FAOPS Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Remarks] 京都府立医科大学 大学院 医学研究科 細胞生理学
  • URL: http://kpum-molecular-cell-physiology.info/index.html