Identification of bona fide circadian pacemaker neurons
| Project/Area Number |
15K15039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Takeshi 筑波大学, 医学医療系, 教授 (60251055)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 概日リズム / 視交叉上核 / 体内時計 / 時計遺伝子 / Bmal1 / AVP / VIP |
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| Outline of Final Research Achievements |
The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we examined the possibility that functional molecular machinery of the circadian clocks only in AVP neurons and VIP neurons, two major neuron types of the SCN, is sufficient for the generation of circadian rhythms of the SCN and behavior, which was not supported by the experimental results. We also obtained several other results, including the observation of diurnal rhythms in the activity of AVP neurons and VIP neurons in SCN slices.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] The intrinsic microglial clock system regulates interleukin-6 expression.2017
Author(s)
Ryota Nakazato, Shogo Hotta, Daisuke Yamada, Miki Kou, Saki Nakamura, Yoshifumi Takahata, Hajime Tei, Rika Numano, Akiko Hida, Shigeki Shimba, Michihiro Mieda, Eiichi Hinoi, Yukio Yoneda and Takeshi Takarada
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Journal Title
Glia
Volume: 65
Issue: 1
Pages: 198-208
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016
Author(s)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
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Journal Title
PLoS ONE
Volume: 11
Issue: 11
Pages: e0164716-e0164716
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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