Neural mechanisms for transmission of emotional information

• Project/Area Number: 15K15042
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: Onaka Tatsushi 自治医科大学, 医学部, 教授 (90177254)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: オキシトシン受容体 / ストレス / オキシトシン / 情動

Outline of Final Research Achievements

When animals are confronted with animals showing negative emotional responses, these animals show similar negative emotional responses. Transmission of negative emotional states has been considered to play an important role in warning other individuals of the same group against the danger. Oxytocin has been reported to facilitate social behavior possibly by increasing the salience of sociosensory cues. However, neural mechanisms remain unclear. The present study suggests that oxytocin receptor-expressing cells within the cortex were activated during exposure to socially-defeated animals.

Research Products

• [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition. (2015)
  • Author(s): Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
  • Journal Title: Biological Psychiatry Volume: in press Issue: 3 Pages: 243-251
  • DOI: 10.1016/j.biopsych.2015.11.021
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Okabe S, Takayanagi Y, Yoshida M
  • Journal Title: Interdisciplinary Information Sciences Volume: 21 Issue: 3 Pages: 189-195
  • DOI: 10.4036/iis.2015.b.03
  • NAID: 110009966527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 社会的敗北とオキシトシン (2017)
  • Author(s): 尾仲達史
  • Organizer: 第27回日本行動神経内分泌研究会
  • Place of Presentation: 牛窓研修センターカリヨンハウス（岡山県瀬戸内市）
  • Year and Date: 2017-04-28
• [Presentation] オキシトシンとストレス、エネルギー代謝、社会行動 (2017)
  • Author(s): 尾仲達史
  • Organizer: 第90回日本内分泌学会学術総会
  • Place of Presentation: ロームシアター京都・京都勧業館みやこめっせ（京都府京都市）
  • Year and Date: 2017-04-20
  • Invited
• [Presentation] Neuroendocrine and behavioral responses to fear-related or affiliative stimuli: roles of oxytocin. (2016)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
• [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: Parvo- and Magnocellular Symposium in Sendai
  • Place of Presentation: Sendai
  • Year and Date: 2015-09-17
  • Int'l Joint Research / Invited