Elucidation of the molecular mechanism of the multifaceted action of DOACs through cyclophilin A receptor

• Project/Area Number: 15K15046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Tohoku University
• Principal Investigator: SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Co-Investigator(Kenkyū-buntansha): 宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 新規抗凝固薬 / サイクロフィリンA / 酸化ストレス / 血管内皮障害 / 動脈硬化 / 血小板活性化 / 血栓塞栓症 / 冠動脈疾患 / 循環器・高血圧 / 血管内皮 / 心筋梗塞

Outline of Final Research Achievements

We are studying the possibility of multifaceted action via inhibitory action of cyclophillin A (CyPA) and its receptor, basigin, by new anticoagulants (DOACs). The significance in the proinflammatory action of the CyPA-Basigin system and the vascular remodeling mechanism, which has not been known at all, has been elucidated, and preparations for publication of the paper are underway. Very interesting findings have been obtained on the possibility of new pharmacological actions of DOACs. We reported these findings and results at international scientific conferences and symposiums both in Japan and abroad (Symposium in the Japanese Circulation Society Annual Scientific meeting, the American Heart Association Annual Scientific meeting, and the European Society of Cardiology Annual Scientific meeting).

Research Products

• [Int'l Joint Research] Stanford University(米国)
• [Journal Article] Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target (2017)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H.
  • Journal Title: Circ Res. Volume: 120 Issue: 8 Pages: 1246
  • DOI: 10.1161/circresaha.117.310640
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] AMPKα2 regulates hypoxia-inducible factor-1α stability and neutrophil survival to promote vascular repair after ischemia. (2017)
  • Author(s): Satoh K
  • Journal Title: Circ Res. Volume: 120 Issue: 1 Pages: 8-10
  • DOI: 10.1161/circresaha.116.310217
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic impacts of plasma levels of cyclophilin a in patients with coronary artery disease (2017)
  • Author(s): Ohtsuki T, Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 37 Issue: 4 Pages: 685
  • DOI: 10.1161/atvbaha.116.308986
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice. (2017)
  • Author(s): Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
  • Journal Title: Diabetologia. Volume: 60 Issue: 6 Pages: 1138-1152
  • DOI: 10.1007/s00125-017-4259-6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice (2016)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
  • Journal Title: Circ Res. Volume: 119 Issue: 2 Pages: 197
  • DOI: 10.1161/circresaha.115.308178
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension (2016)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 6 Pages: 1293
  • DOI: 10.1161/atvbaha.115.306845
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel therapeutic targets of pulmonary hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 12
  • DOI: 10.1161/atvbaha.116.308263
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] RhoA/Rho-kinase in the cardiovascular system. (2016)
  • Author(s): Shimokawa H, Sunamura S, Satoh K.
  • Journal Title: Circ Res. Volume: 118 Issue: 2 Pages: 352-366
  • DOI: 10.1161/circresaha.115.306532
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 4 Pages: 636
  • DOI: 10.1161/atvbaha.115.306686
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis: Novel mechanism of the pleiotropic effects of statins (2016)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
  • Journal Title: Hypertension Volume: 67 Issue: 5 Pages: 878
  • DOI: 10.1161/hypertensionaha.115.07089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells (2016)
  • Author(s): Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
  • Journal Title: Cardiovasc Res. Volume: 109 Issue: 1 Pages: 151
  • DOI: 10.1093/cvr/cvv253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Balloon pulmonary angioplasty improves biventricular functions and pulmonary flow in patients with chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circ J. Volume: 80
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PDE1C negatively regulates growth factor receptor degradation and promotes vascular smooth muscle cell proliferation. (2015)
  • Author(s): Satoh K, Kikuchi N, Kurosawa R, Shimokawa H.
  • Journal Title: Circ Res. Volume: 116 Issue: 7 Pages: 1098-1100
  • DOI: 10.1161/circresaha.115.306139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A in Cardiovascular Homeostasis and Diseases (2015)
  • Author(s): Satoh K
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 1-15
  • DOI: 10.1620/tjem.235.1
  • NAID: 130004822422
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice (2015)
  • Author(s): Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 10 Pages: 2172
  • DOI: 10.1161/atvbaha.115.305872
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 2015 ATVB plenary lecture: translational research on Rho-kinase in cardiovascular medicine. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 8 Pages: 1756-1769
  • DOI: 10.1161/atvbaha.115.305353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Light and dark of reactive oxygen species for vascular function. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: 65 Issue: 5 Pages: 412-418
  • DOI: 10.1097/fjc.0000000000000159
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A: Novel biomarker for oxidative stress and cardiovascular diseases. (2015)
  • Author(s): Satoh K, Shimokawa H.
  • Journal Title: In: Preedy VR, Patel VB (eds), General Methods in Biomarker Research and Their Applications Volume: Springer Reference, London Pages: 405-438
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Cyclophilin A and Its Receptor Basigin Promote Vascular Smooth Muscle Proliferation and Pulmonary Hypertension ―Possible Novel Therapeutic Target Pathway― (2016)
  • Author(s): Satoh K.
  • Organizer: 第80回日本循環器学会学術集会プレナリーセッション(PL08:Progress and Future in Pulmonary Hypertension Clinic)
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] ＜Plenary Session＞ Emerging Role of the Heart-Brain Axis via the Hippocampus in the Pathogenesis of Heart Failure. (2016)
  • Author(s): Suzuki H, Matsumoto Y, Sumiyoshi A, Kaneta T, Ota H, Yoshikawa T, Sugimura K, Aoki T, Tatebe S, Miura M, Takahashi J, Satoh K, Miyata S, Ito K, Furukawa K, Fukumoto Y, Arai H, Yanai K, Kawashima R, Taki Y, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Plenary Session＞ Cyclophilin A and Its Receptor Basigin Promote Vascular Smooth Muscle Proliferation and Pulmonary Hypertension ―Possible Novel Therapeutic Target Pathway― (2016)
  • Author(s): Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Miura M, Yaoita N, Fukumoto Y, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Symposium＞ Crucial Role of Thrombin-Activated Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Horiuchi H, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Special Session＞(SS06:Novel Therapeutic Targets in Cardiovascular Disease) Crucial Roles of Rho-kinase, Cyclophilin A and Its Receptor, Basigin, for Cardiac Hypertrophy, Fibrosis and Failure―Novel Therapeutic Targets of Heart Failure― (2016)
  • Author(s): Satoh K, Suzuki K, Sunamura S , Otsuki T, Shimizu T, Ikeda I, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Topic＞ Pathophysiology and Treatment of Right Heart Failure in Patients with Pulmonary Hypertension. (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Meet the Expert＞ Efficacy and Safety of Balloon Pulmonary Angioplasty in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Meet the Expert＞(ME05:Use of Bio-makers in the Cardiovascular Medicine) Cyclophilin A: A Novel Biomarker for Patients with Coronary Artery Disease. (2016)
  • Author(s): Satoh K, Otsuki T, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Featured Research Session＞ (FRS06:Heart Failure, Basic and Cardiac Function) Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure-Overload in Mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Francis G Spinale, Kadomatsu K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Featured Research Session＞(FRS19:Heart Failure, Pulmonary Hypertension) Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension ―A Possible Novel Therapeutic Target― (2016)
  • Author(s): Kikuchi N, Satoh K, Omura J, Sato T, Kurosawa R, Nogi M, Otsuki T, Numano K, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Featured Research Session＞(FRS19:Heart Failure, Pulmonary Hypertension) Involvement of Thrombin Activatable Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Suzuki K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞(OE32:Atherosclerosis, Clinical 1) Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients with Coronary Artery Disease. (2016)
  • Author(s): Otsuki T, Satoh K, Sugimura K Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞(OE44:Heart Failure, Basic 2) Crucial Role of ROCK1 to Maintain Contractile Function in Response to Pressure-Overload in Mice. (2016)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Ikeda S, Omura J, Kikuchi N, Sato Th, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞(OE48:Atherosclerosis, Clinical 2) Prognostic Impacts of Plasma Levels of Adipsin in Patients with Coronary Artery Disease. (2016)
  • Author(s): Otsuki T, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞(OE59:CTEPH BPA) Plasma Cyclophilin A as a Useful Biomarker for the Effects of Percutaneous Transluminal Pulmonary Angioplasty in Patients with CTEPH. (2016)
  • Author(s): Kozu K, Satoh K, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Effects of Percutaneous Transluminal Pulmonary Angioplasty on Oxygenation Capacity in Patients with Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Aoki T, Sugimura K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (Japanese)＞(OJ12:Pulmonary Circulation) Disruption of Endothelial AMP-activated Protein Kinase Worsens Hypoxia-induced Pulmonary Hypertension in Mice. (2016)
  • Author(s): Omura J, Satoh K, Kikuchi N, Sato T, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Influence of Discontinuation of Medications after Successful Percutaneous Transluminal Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Yaoita N, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Miura M, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Percutaneous Transluminal Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Kouzu K, Satoh K, Takase K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice. (2016)
  • Author(s): Satake Y, Kaiho Y, Satoh K, Yamashita S, Tsutsui M, Shimokawa H, Arai Y.
  • Organizer: 31st Annual European association of urology (EAU) Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-03-11
  • Int'l Joint Research
• [Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-（Travel Award受賞） (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T , NumanoK, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Effects of PTPA on respiratory functions in patients with CTEPH. (2015)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. （Travel Award受賞） (2015)
  • Author(s): Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Otuki T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Endothelial AMPK exerts protective effects against hypoxia-induced pulmonary hypertension in mice in vivo. (2015)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Crucial role of thrombin activatable fibrinolysis inhibitor in the pathogenesis of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi K, Omura J, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Plasma cyclophilin A as a useful biomarker for evaluation of the effects of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Kozu K, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] ＜YIA審査講演：基礎系＞（YIA受賞）Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2015)
  • Author(s): Suzuki K, Satoh K, Omura J, Sato T, Kudo S, Otsuki T, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-10-22
• [Presentation] ＜YIA審査講演：臨床系＞（Finalist）Prognostic impacts of plasma levels of cyclophilin A in patients with heart failure. (2015)
  • Author(s): Otsuki T, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Miyata S, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-10-22
• [Presentation] ＜ワークショップ6：心不全基礎研究の最前線＞ Crucial roles of Rho-kinase, cyclophilin A and its receptor, basigin, for cardiac hypertrophy, fibrosis and failure -novel therapeutic targets- (2015)
  • Author(s): Satoh K, Suzuki K, Sunamura S, Otsuki T, Shimizu T, Ikeda S, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-10-22
• [Presentation] ROCK1 plays a crucial role to maintain cardiac function in response to pressure-overload in mice. (2015)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-10-22
• [Presentation] サイクロフィリンAによる肺高血圧症促進機構とその臨床応用 (2015)
  • Author(s): 佐藤 公雄.
  • Organizer: 第4回日本肺循環学会・第3回日本肺高血圧学会 合同学術集会シンポジウム
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
  • Invited
• [Presentation] ＜YIAセッション＞ CTEPH における新規病因蛋白 TAFI の基礎的・臨床的機能解析 (2015)
  • Author(s): 佐藤 大樹、佐藤 公雄、矢尾板 信裕、菊地 順裕、大村 淳一、黒澤 亮、杉村 宏一郎、中村 一文、伊藤 浩、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] ＜シンポジウム8：肺高血圧治療薬の肺血管以外への作用を介した肺高血圧病態改善の可能性＞ サイクロフィリン A による肺高血圧症促進機構とその臨床応用. (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 肺動脈血管内皮 AMPK は肺高血圧症の進行を抑制する. (2015)
  • Author(s): 大村 淳一、佐藤 公雄、菊地 順裕、佐藤 大樹、黒澤 亮、神津 克也、沼野 和彦、青木 竜男、建部 俊介、杉村 宏一郎、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 化合物スクリーニングによる新規肺高血圧症治療薬の開発. (2015)
  • Author(s): 黒澤 亮、佐藤 公雄、菊地 順裕、大村 淳一、佐藤 大樹、野木 正道、沼野 和彦、Mohammad Siddique、Elias Al-Mamun、杉村 宏一郎、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 新規病因蛋白セレノプロテイン P による肺高血圧症促進機構 (2015)
  • Author(s): 菊地 順裕、佐藤 公雄、大村 淳一、佐藤 大樹、黒澤 亮、野木 正道、大槻 知広、建部 俊介、青木 竜男、杉村 宏一郎、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 慢性血栓塞栓性肺高血圧症の病因における TAFI の関与 (2015)
  • Author(s): 矢尾板 信裕、佐藤 公雄、佐藤 大樹、杉村 宏一郎、青木 竜男、三浦 正暢、建部 俊介、福本 義弘、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 血漿中サイクロフィリン A は PTPA 治療の有効性を反映する. (2015)
  • Author(s): 佐藤 公雄、杉村 宏一郎、青木 竜男、建部 俊介、三浦 正暢、矢尾板 信裕、鈴木 秀明、山本 沙織、神津 克也、大槻 知広、下川 宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] Role of cyclophilin A in cardiovascular system (2015)
  • Author(s): 佐藤 公雄.
  • Organizer: 第40回日本微小循環学会主催 サテライトシンポジウム
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2015-09-24
  • Invited
• [Presentation] 慢性血栓塞栓性肺高血圧症の病因におけるTAFIの役割とその機能的意義 (2015)
  • Author(s): 矢尾板 信裕、佐藤 公雄、杉村 宏一郎、青木 竜男、三浦 正暢、建部 俊介、下川 宏明
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-18
• [Presentation] 血漿中サイクロフィリンAによる冠動脈疾患の長期予後予測 (2015)
  • Author(s): 大槻 知広、佐藤 公雄、杉村 宏一郎、青木 竜男、建部 俊介、三浦 正暢、山本 沙織、矢尾板 信裕、鈴木 秀明、佐藤 遥、神津 克也、二瓶 太郎、高橋 潤、宮田 敏、下川 宏明
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-09-18
• [Presentation] <Hot Line session> Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension-A Possible Novel Therapeutic Target- (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] <Best posters> Cardiac pacemaker stimulates the brain as well as the heart in humans &#8211;A PET functional study- (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto M, Kondo M, Nakano M, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Novel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging. (2015)
  • Author(s): Sugimura K, Aoki T, Miura M, Yaoita N, Satoh H, Satoh K, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis -Novel Mechanism of the Pleiotropic Effects of Statins- (2015)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Tanaka S, Minami T, Ikeda S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Levels of Cyclophilin A Correlate with Circulating Inflammatory Cytokines in Patients with Pulmonary Hypertension. (2015)
  • Author(s): Otsuki T, Satoh K, Kikuchi N, Omura J, Kudo S, Sugimura K, Aoki T, Tatebe S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Cyclophilin A as a Useful Biomarker for Effective Percutaneous Transluminal Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. (2015)
  • Author(s): Satoh K, Sugimura K, Aoki T, Tatebe S, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Otsuki T, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] ＜Plenary Session＞ 1.(PL01: New Multi-Modality Cardiovascular Imaging and the Dedicated Management of Diseases) 4D flow MRI for pulmonary hypertension: an imaging tool to monitor mean pulmonary arterial pressure. (2015)
  • Author(s): Ota H, Sugimura K, Nochioka K, Tatebe S, Yamamoto S, Miura M, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Plenary Session＞2.(SY13:Recent Progress in Pulmonary Hypertension) Importance of acute hemodynamic responses to inhaled nitric oxide in patients with pulmonary hypertension due to left heart disease. (2015)
  • Author(s): Aoki T, Tatebe S, Sugimura K, Nochioka K, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Round Table Discussion＞ (TP05:Diagnosis and Treatment of Chronic Thromboembolic Pulmonary Hypertension after an Advent and Development of Balloon Pulmonary Angioplasty)Usefulness of optical coherence tomography imaging in management of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Sugimura K, Aoki T, Tatebe S, Miura M, Yaoita N, Sato H, Kato T, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Young Investigator's Award for International Students Finalists Lectures＞Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension through synergistic inhibition of Rho-kinase. (2015)
  • Author(s): Elias-Al-Mamun M, Satoh K, Tanaka S, Shimizu T, Nergui S, Miyata S, Fukumoto Y, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Featured Research Session＞ Plasma Cyclophilin A as a useful biomarker for effective percutaneous transluminal pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh K , Sugimura K , Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Nogi M, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞ 6.(OE-033:Heart Failure (Basic) and Translational Science) Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2015)
  • Author(s): Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞(OE-307: Cardiomyopathy/Hypertrophy (Basic)) Crucial role of SmgGDS in the inhibitory effects of statins on cardiac hypertrophy and fibrosis in mice. (2015)
  • Author(s): Kudo S, Satoh K, Suzuki K, Sunamura S, Nogi M, Kikuchi N, Ohmura J, Ikeda S, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞ Endothelial cell-specific AMPK deletion accelerates hypoxia-induced pulmonary hypertension in mice in vivo. (2015)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Suzuki K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞ Plasma levels of Cyclophilin A correlate with circulating inflammatory cytokines in patients with pulmonary hypertension. (2015)
  • Author(s): Satoh K, Suzuki K, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Nogi M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (English)＞ Thrombin activatable fibrinolysis inhibitor plays a crucial role in the pathogenesis of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Suzuki K, Kudo S, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Oral Presentation (Japanese)＞ Involvement of thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Yaoita N, Taiju Sato , Satoh K, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Effects of PTPA on respiratory functions in patients with chronic thromboembolic pulmonary hypertension―Possible importance of intra-pulmonary shunt― (2015)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Usefulness of cardiac MRI for evaluating the effectiveness of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Sato H, Miura M, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Ota H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Evidence for activation of cerebral autonomic center in response to cardiac electrical stimulation in humans―New finding of cardio-cerebral connection― (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano M, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Effectiveness of vasodilator therapy for patients with inoperable chronic thromboembolic pulmonary hypertension in prior to percutaneous transluminal pulmonary angioplasty. (2015)
  • Author(s): Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Current status of the treatment for adult congenital heart disease associated with pulmonary arterial hypertension. (2015)
  • Author(s): Sato H, Tatebe S, Sugimura K, Aoki T, Miura M, Yaoita N, Nochioka K , Yamamoto S, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] 喫煙による酸化ストレスと動脈硬化性疾患 (2015)
  • Author(s): 佐藤公雄.
  • Organizer: 第79回日本循環器学会学術集会 禁煙推進委員会・第14回禁煙推進セミナー
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Book] Diagnosis and Treatment of Pulmonary Hypertension. From Bench to Bedside (2017)
  • Author(s): Satoh K, Sugimura K, Shimokawa H.
  • Total Pages: 236
  • Publisher: Springer Nature, Singapore
• [Book] 循環器専門医 「喫煙と循環器疾患up to date: 喫煙による酸化ストレスと動脈硬化性疾患」 (2016)
  • Author(s): 佐藤 公雄.
  • Total Pages: 5
  • Publisher: 南江堂
• [Book] 循環器内科 特集/循環器疾患と分子遺伝学 「肺高血圧症の分子基盤」 (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp
• [Patent(Industrial Property Rights)] セレノプロテインＰ活性阻害作用を有する成分を含有する、肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-121034
  • Filing Date: 2016-06-17
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明, 徳山英利, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Holder: 下川宏明, 徳山英利, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-120901
  • Filing Date: 2016-06-17
• [Patent(Industrial Property Rights)] 不飽和複素５員環含有化合物を含有する肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明, 大島吉輝, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Holder: 下川宏明, 大島吉輝, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-140474
  • Filing Date: 2016-07-15
• [Patent(Industrial Property Rights)] PPARαアゴニストを含有する、肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-141942
  • Filing Date: 2016-07-20
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-160588
  • Filing Date: 2016-08-18
• [Patent(Industrial Property Rights)] 肺高血圧症の検査方法 (2015)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-01
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