Elucidation of the molecular mechanism of the multifaceted action of DOACs through cyclophilin A receptor
Project/Area Number |
15K15046
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Tohoku University |
Principal Investigator |
SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
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Co-Investigator(Kenkyū-buntansha) |
宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 新規抗凝固薬 / サイクロフィリンA / 酸化ストレス / 血管内皮障害 / 動脈硬化 / 血小板活性化 / 血栓塞栓症 / 冠動脈疾患 / 循環器・高血圧 / 血管内皮 / 心筋梗塞 |
Outline of Final Research Achievements |
We are studying the possibility of multifaceted action via inhibitory action of cyclophillin A (CyPA) and its receptor, basigin, by new anticoagulants (DOACs). The significance in the proinflammatory action of the CyPA-Basigin system and the vascular remodeling mechanism, which has not been known at all, has been elucidated, and preparations for publication of the paper are underway. Very interesting findings have been obtained on the possibility of new pharmacological actions of DOACs. We reported these findings and results at international scientific conferences and symposiums both in Japan and abroad (Symposium in the Japanese Circulation Society Annual Scientific meeting, the American Heart Association Annual Scientific meeting, and the European Society of Cardiology Annual Scientific meeting).
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Report
(3 results)
Research Products
(96 results)
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[Journal Article] Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension -A possible novel therapeutic target-2017
Author(s)
Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H.
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Journal Title
Circ Res.
Volume: 120
Issue: 8
Pages: 1246-1262
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Prognostic impacts of plasma levels of cyclophilin A in patients with coronary artery disease.2017
Author(s)
Ohtsuki T, Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 37
Issue: 4
Pages: 685-693
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.2017
Author(s)
Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
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Journal Title
Diabetologia.
Volume: 60
Issue: 6
Pages: 1138-1152
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Protective roles of endothelial AMP-activated protein kinase against hypoxia-induced pulmonary hypertension in mice.2016
Author(s)
Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
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Journal Title
Circ Res.
Volume: 119
Issue: 2
Pages: 197-209
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension.2016
Author(s)
Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 6
Pages: 1293-1301
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice.2016
Author(s)
Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 4
Pages: 636-646
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis -Novel mechanism of the pleiotropic effects of statins-2016
Author(s)
Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
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Journal Title
Hypertension
Volume: 67
Issue: 5
Pages: 878-889
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension2016
Author(s)
Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
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Journal Title
Circulation Journal
Volume: 80
Issue: 4
Pages: 980-988
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Balloon pulmonary angioplasty improves biventricular functions and pulmonary flow in patients with chronic thromboembolic pulmonary hypertension.2016
Author(s)
Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice.2015
Author(s)
Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 35
Issue: 10
Pages: 2172-2184
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] <Plenary Session> Emerging Role of the Heart-Brain Axis via the Hippocampus in the Pathogenesis of Heart Failure.2016
Author(s)
Suzuki H, Matsumoto Y, Sumiyoshi A, Kaneta T, Ota H, Yoshikawa T, Sugimura K, Aoki T, Tatebe S, Miura M, Takahashi J, Satoh K, Miyata S, Ito K, Furukawa K, Fukumoto Y, Arai H, Yanai K, Kawashima R, Taki Y, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Plenary Session> Cyclophilin A and Its Receptor Basigin Promote Vascular Smooth Muscle Proliferation and Pulmonary Hypertension ―Possible Novel Therapeutic Target Pathway―2016
Author(s)
Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Miura M, Yaoita N, Fukumoto Y, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Symposium> Crucial Role of Thrombin-Activated Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension.2016
Author(s)
Yaoita N, Satoh K, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Horiuchi H, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Special Session>(SS06:Novel Therapeutic Targets in Cardiovascular Disease) Crucial Roles of Rho-kinase, Cyclophilin A and Its Receptor, Basigin, for Cardiac Hypertrophy, Fibrosis and Failure―Novel Therapeutic Targets of Heart Failure―2016
Author(s)
Satoh K, Suzuki K, Sunamura S , Otsuki T, Shimizu T, Ikeda I, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Topic> Pathophysiology and Treatment of Right Heart Failure in Patients with Pulmonary Hypertension.2016
Author(s)
Tatebe S, Sugimura K, Aoki T, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Meet the Expert> Efficacy and Safety of Balloon Pulmonary Angioplasty in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension.2016
Author(s)
Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Featured Research Session> (FRS06:Heart Failure, Basic and Cardiac Function) Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure-Overload in Mice.2016
Author(s)
Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Francis G Spinale, Kadomatsu K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Featured Research Session>(FRS19:Heart Failure, Pulmonary Hypertension) Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension ―A Possible Novel Therapeutic Target―2016
Author(s)
Kikuchi N, Satoh K, Omura J, Sato T, Kurosawa R, Nogi M, Otsuki T, Numano K, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Featured Research Session>(FRS19:Heart Failure, Pulmonary Hypertension) Involvement of Thrombin Activatable Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension.2016
Author(s)
Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Suzuki K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (English)>(OE32:Atherosclerosis, Clinical 1) Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients with Coronary Artery Disease.2016
Author(s)
Otsuki T, Satoh K, Sugimura K Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (English)>(OE44:Heart Failure, Basic 2) Crucial Role of ROCK1 to Maintain Contractile Function in Response to Pressure-Overload in Mice.2016
Author(s)
Sunamura S, Satoh K, Suzuki K, Ikeda S, Omura J, Kikuchi N, Sato Th, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (English)>(OE48:Atherosclerosis, Clinical 2) Prognostic Impacts of Plasma Levels of Adipsin in Patients with Coronary Artery Disease.2016
Author(s)
Otsuki T, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (English)>(OE59:CTEPH BPA) Plasma Cyclophilin A as a Useful Biomarker for the Effects of Percutaneous Transluminal Pulmonary Angioplasty in Patients with CTEPH.2016
Author(s)
Kozu K, Satoh K, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] Effects of Percutaneous Transluminal Pulmonary Angioplasty on Oxygenation Capacity in Patients with Chronic Thromboembolic Pulmonary Hypertension.2016
Author(s)
Aoki T, Sugimura K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Satoh K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (Japanese)>(OJ12:Pulmonary Circulation) Disruption of Endothelial AMP-activated Protein Kinase Worsens Hypoxia-induced Pulmonary Hypertension in Mice.2016
Author(s)
Omura J, Satoh K, Kikuchi N, Sato T, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] Percutaneous Transluminal Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension.2016
Author(s)
Sato H, Ota H, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Kouzu K, Satoh K, Takase K, Shimokawa H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-(Travel Award受賞)2015
Author(s)
Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T , NumanoK, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Effects of PTPA on respiratory functions in patients with CTEPH.2015
Author(s)
Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (Travel Award受賞)2015
Author(s)
Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Otuki T, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Endothelial AMPK exerts protective effects against hypoxia-induced pulmonary hypertension in mice in vivo.2015
Author(s)
Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Crucial role of thrombin activatable fibrinolysis inhibitor in the pathogenesis of chronic thromboembolic pulmonary hypertension.2015
Author(s)
Satoh T, Satoh K, Yaoita N, Kikuchi K, Omura J, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] Plasma cyclophilin A as a useful biomarker for evaluation of the effects of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension.2015
Author(s)
Kozu K, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
Organizer
American Heart Association (AHA) Scientific Sessions
Place of Presentation
Orlando, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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[Presentation] <ワークショップ6:心不全基礎研究の最前線> Crucial roles of Rho-kinase, cyclophilin A and its receptor, basigin, for cardiac hypertrophy, fibrosis and failure -novel therapeutic targets-2015
Author(s)
Satoh K, Suzuki K, Sunamura S, Otsuki T, Shimizu T, Ikeda S, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
Organizer
第19回日本心不全学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-10-22
Related Report
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[Presentation] <Hot Line session> Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension-A Possible Novel Therapeutic Target-2015
Author(s)
Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
Organizer
European Society Congress (ESC) 2015
Place of Presentation
London, UK
Year and Date
2015-08-29
Related Report
Int'l Joint Research
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[Presentation] <Best posters> Cardiac pacemaker stimulates the brain as well as the heart in humans –A PET functional study-2015
Author(s)
Suzuki H, Satoh K, Tatebe S, Matsumoto M, Kondo M, Nakano M, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H.
Organizer
European Society Congress (ESC) 2015
Place of Presentation
London, UK
Year and Date
2015-08-29
Related Report
Int'l Joint Research
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[Presentation] SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis -Novel Mechanism of the Pleiotropic Effects of Statins-2015
Author(s)
Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Tanaka S, Minami T, Ikeda S, Shimokawa H.
Organizer
Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
Place of Presentation
San Francisco, USA
Year and Date
2015-05-08
Related Report
Int'l Joint Research
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[Presentation] Plasma Levels of Cyclophilin A Correlate with Circulating Inflammatory Cytokines in Patients with Pulmonary Hypertension.2015
Author(s)
Otsuki T, Satoh K, Kikuchi N, Omura J, Kudo S, Sugimura K, Aoki T, Tatebe S, Shimokawa H.
Organizer
Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
Place of Presentation
San Francisco, USA
Year and Date
2015-05-08
Related Report
Int'l Joint Research
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[Presentation] Plasma Cyclophilin A as a Useful Biomarker for Effective Percutaneous Transluminal Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension.2015
Author(s)
Satoh K, Sugimura K, Aoki T, Tatebe S, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Otsuki T, Shimokawa H.
Organizer
Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
Place of Presentation
San Francisco, USA
Year and Date
2015-05-08
Related Report
Int'l Joint Research
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[Presentation] <Featured Research Session> Plasma Cyclophilin A as a useful biomarker for effective percutaneous transluminal pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.2015
Author(s)
Satoh K , Sugimura K , Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Nogi M, Shimokawa H.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (English)> Plasma levels of Cyclophilin A correlate with circulating inflammatory cytokines in patients with pulmonary hypertension.2015
Author(s)
Satoh K, Suzuki K, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Nogi M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Aoki T, Sugimura K, Shimokawa H.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24
Related Report
Int'l Joint Research
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[Presentation] <Oral Presentation (Japanese)> Involvement of thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension.2015
Author(s)
Yaoita N, Taiju Sato , Satoh K, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Horiuchi H, Fukumoto Y, Shimokawa H.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24
Related Report
Int'l Joint Research
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[Presentation] Evidence for activation of cerebral autonomic center in response to cardiac electrical stimulation in humans―New finding of cardio-cerebral connection―2015
Author(s)
Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano M, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24
Related Report
Int'l Joint Research
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