A new mice model of bipolar disease for the drug developments
| Project/Area Number |
15K15050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
Nitta Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
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| Co-Investigator(Kenkyū-buntansha) |
宮本 嘉明 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20449101)
宇野 恭介 富山大学, 大学院医学薬学研究部(薬学), 助教 (30608774)
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| Co-Investigator(Renkei-kenkyūsha) |
Muramatsu Shin-Ichi 自治医科大学, 医学部, 教授 (10239543)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ピッコロ / 双極性障害 / 光遺伝学 / マウスモデル / ＡＡＶ / 行動実験 / Piccolo / in vivo マイクロダイアリシス / 光刺激反応 / マウス / 電気生理 / in vivo マイクロダイアリシス法 / 光刺激反応実験 |
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| Outline of Final Research Achievements |
Bipolar disorder has both mania and depression phase and is occurred in adolescent period in human. There were no model animals when our study was started, because the cause of the disease was not clear, then there was no fundamental therapeutic medicines. We succeeded in creating bipolar disorder model mice by knock down of the psychological diseases-related molecule “Piccolo” in the frontal cortex. Furthermore, in order to elucidate the cause of bipolar disorder using this model, we conducted the optogenetics and the in vivo microdialysis method or multi-electrode extracellular potential recording system. We clarified the cause of the pathogenesis of bipolar disorder in part at the least. The mice model should be used for novel therapies for the bipolar disorder.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] Methamphetamine induces2017
Author(s)
Uno K, Miyazaki T, Sodeyama K, Miyamoto Y, Nitta A.
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Journal Title
PLoS One
Volume: 12
Issue: 3
Pages: e0174196-e0174196
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype2016
Author(s)
Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
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Journal Title
PLoS One
Volume: 11
Issue: 6
Pages: e0157959-e0157959
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate.2015
Author(s)
Toriumi K, Mamiya T, Song Z, Honjo T, Watanabe H, Tanaka J, Kondo M, Mouri A, Kim HC, Nitta A, Fukushima T, Nabeshima T.
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Journal Title
Eur Neuropsychopharmacol.
Volume: 25(11)
Issue: 11
Pages: 2108-17
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study.2015
Author(s)
Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A
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Journal Title
Curr Mol Med
Volume: 15
Pages: 265-274
Related Report
Peer Reviewed
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[Journal Article] Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: compatibility study with morphine and metoclopramide injections.2015
Author(s)
Tanabe K, Wada J, Ohkubo J, Nitta A, Ikezaki T, Takeuchi M, Handa A, Tanaka M, Murakami N, Kashii T, Kitazawa H. Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: compatibility study with morphine and metoclopramide injections
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Journal Title
Eur J Hosp Pharm Sci Pract
Volume: 22
Pages: 171-175
Related Report
Peer Reviewed
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[Presentation] 薬学系大学院教育におけるインターンシップについて－富山大学薬学系大学院で実施している製薬企業・病院薬剤師でのインターンシップ－2016
Author(s)
新田淳美, 細谷健一, 新山雅夫, 松原利行, 龍伸和, 周徳軍, 徐承姫, 済木育夫, 柴原利直, 門脇真, 今中常雄
Organizer
第1回日本薬学教育学会大会
Place of Presentation
京都
Year and Date
2016-08-27
Related Report
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[Presentation] Knockdown Piccolo suppressed Methamphetamine-induced behavioral changes and dopamine release in the nucleus accumbens of mice2016
Author(s)
Ge B, Morishita S, Uno K, Muramatsu S, Nabeshima T, Miyamoto Y, Nitta A,
Organizer
Ge B, Morishita S, Uno K, Muramatsu S, Nabeshima T, Miyamoto Y, Nitta A,
Place of Presentation
韓国 ソウル
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] 精神疾患患者における末梢血中SHATI/NAT8LのDNAメチル化率の低下2015
Author(s)
田美奈, 宇野恭介 ,宮崎杜夫, 袖山健吾, 山森英長, 藤本美智子, 安田由華, 橋本亮太, 宮本嘉明, 鍋島俊隆, 武田雅俊, 新田淳美
Organizer
第45回日本神経精神薬理学会年会
Place of Presentation
東京
Year and Date
2015-09-24
Related Report
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[Book] 脳２１2016
Author(s)
新田淳美、宇野恭介、鍋島俊隆、宮本嘉明
Total Pages
92
Publisher
金芳堂
Related Report
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