| Project/Area Number |
15K15054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Osaka City University (2016)
Tottori University (2015) |
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Principal Investigator |
Tomita Shuhei 大阪市立大学, 大学院医学研究科, 教授 (00263898)
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| Co-Investigator(Kenkyū-buntansha) |
松永 慎司 大阪市立大学, 大学院医学研究科, 助教 (30704910)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍血管 / 低酸素 / PHD阻害剤 / HIF / 血管リモデリング / 癌微小環境 |
|---|
| Outline of Final Research Achievements |
In tumor tissue, abnormal blood vessels, which are hyper-permeable and immature, are often formed; these tissues also have irregular vascularization and intravasation. This environment induces resistance to anticancer drugs, which causes an increase in anticancer drug doses, leading to increased side effects. We hypothesized that normalized tumor blood vessels would improve tumor tissue perfusion, resupply nutrition and re-oxygenate the tumor tissue. Chemotherapy would then be more effective and cause a decrease in anticancer drug doses. We report a neovascularization-inducing drug that improved tumor vascular abnormalities, such as low blood flow, blood leakage and abnormal vessel structure. These results could lead to not only an increased chemo-sensitivity and tissue-drug distribution but also an up-regulated efficiency for cancer chemotherapy. This suggests that tumor blood vessel normalization therapy accompanied by angiogenesis may be a novel strategy for cancer therapy.
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