Tumor blood vessel normalization by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumor mouse model
| Project/Area Number |
15K15054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Osaka City University (2016)
Tottori University (2015) |
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Principal Investigator |
Tomita Shuhei 大阪市立大学, 大学院医学研究科, 教授 (00263898)
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| Co-Investigator(Kenkyū-buntansha) |
松永 慎司 大阪市立大学, 大学院医学研究科, 助教 (30704910)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍血管 / 低酸素 / PHD阻害剤 / HIF / 血管リモデリング / 癌微小環境 |
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| Outline of Final Research Achievements |
In tumor tissue, abnormal blood vessels, which are hyper-permeable and immature, are often formed; these tissues also have irregular vascularization and intravasation. This environment induces resistance to anticancer drugs, which causes an increase in anticancer drug doses, leading to increased side effects. We hypothesized that normalized tumor blood vessels would improve tumor tissue perfusion, resupply nutrition and re-oxygenate the tumor tissue. Chemotherapy would then be more effective and cause a decrease in anticancer drug doses. We report a neovascularization-inducing drug that improved tumor vascular abnormalities, such as low blood flow, blood leakage and abnormal vessel structure. These results could lead to not only an increased chemo-sensitivity and tissue-drug distribution but also an up-regulated efficiency for cancer chemotherapy. This suggests that tumor blood vessel normalization therapy accompanied by angiogenesis may be a novel strategy for cancer therapy.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice.2017
Author(s)
Islam J, Sato S, Watanabe K, Watanabe T, Ardiansyah, Hirahara K, Aoyama Y, Tomita S, Aso H, Komai M, Shirakawa H
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Journal Title
J Nutr Biochem
Volume: 42
Pages: 43-50
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Use of tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer.2017
Author(s)
Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Noda S, Takashima T, Onoda N, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
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Journal Title
PLoS ONE
Volume: 12
Issue: 2
Pages: e0170634-e0170634
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A Long-Term High-Fat Diet Changes Iron Distribution in the Body, Increasing Iron Accumulation Specifically in the Mouse Spleen2015
Author(s)
Noriko Yamano, Yasumasa Ikeda, Minoru Sakama, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Licht Miyamoto, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: 1
Pages: 20-27
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The effect of antioxidants treatment on Seminal Vesicles and Vas Deferens function in the Diabetes Mellitus rat model.2015
Author(s)
Panagiota Tsounapi, Masashi Honda, Shinji Hirano, Bunya Kawamoto, Katsuya Hikita, Kuniyasu Muraoka, Michiyo Iguchi, Masaki Imanishi, Shinji Matsunaga, Shuhei Tomita, Takehiro Sejima, Atsushi Takenaka.
Organizer
The 103rd Annual Meeting of the Japanese Urological Association
Place of Presentation
Kanazawa(Kanazawa Art Hall（石川県金沢市）)
Year and Date
2015-08-18
Related Report
Int'l Joint Research
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