| Project/Area Number |
15K15063
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Aichi Gakuin University (2016-2017)
Nagoya University (2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIRATA Takefumi 東京大学, 大学院理学系研究科, 教授 (10251612)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 癌転移 / 微量金属 / 質量分析 / 癌組織 / 脱タンパク質法 / 金属元素 / メタロミクス / スキルス胃癌 / 微量金属測定 / ICP-MS / 金属輸送タンパク質 / 遺伝子発現制御 / 癌治療 / 金属輸送蛋白質 |
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| Outline of Final Research Achievements |
We successfully established to comprehensively measure the amounts of trace metals in cancer cells/tissues via ICP-MS method. Prior to ICP-MS, we performed deproteinization by trichloroacetic acid treatment. Using our method, we showed rubidium (atomic number 37) contents were significantly high in metastatic cell line from human scirrhous gastric cancers compared with the non-metastatic parental cell line. As the next experimental project, we obtained a precious cue to research the relationship between cancer metastasis and rubidium contents.
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