| Project/Area Number |
15K15067
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 褐色脂肪細胞 / 小胞体ストレス / センサー / UCP1 / IRE1 / BBF2H7 |
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| Outline of Final Research Achievements |
Brown adipose tissue (BAT) is a key tissue that controls the energy balance of whole body. Brown adipocytes are able to dissipate energy in the form of heat owing to their mitochondrial protein, uncoupling protein 1 (UCP1). Because the energy consumption system in BAT is attractive for counteracting obesity and its related metabolic diseases, it is important to understand the mechanism responsible for regulating thermogenesis. In this study, we focused on the signal which originates from endoplasmic reticulum. We found IRE1-XBP1 branch is activated during the thermogenesis in brown adipocytes. In addition, it is demonstrated that PKA-dependent IRE1-XBP1 activation is crucial for the transcriptional induction of UCP1 in brown adipocytes.
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