| Project/Area Number |
15K15078
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
Suda Takashi 金沢大学, がん進展制御研究所, 教授 (70250090)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Norihisa 広島大学, 生物圏科学研究科, 教授 (20144892)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ビタミンB6 / IL-1β / NLRP3 / endotoxin shock / NF-κB / インフラマソーム |
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| Outline of Final Research Achievements |
In this study, we found that among B6 vitamers, pyridoxal (PL) and pyridoxal phosphate (PLP) inhibits IL-1β secretion from macrophages. Analyses of molecular mechanisms indicated that PL and PLP inhibits both Tak1 phosphorylation mediated by Toll-like receptors and following proIL-1β expression, and NLRP3-dependent caspase-1 activation and following proIL-1β processing into its mature form. Furthermore, administration of PL or PLP ameliorated lipopolysaccharide-induced endotoxin shock in mice. These results suggested that vitamin B6 is useful to prevent inflammatory diseases.
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