| Project/Area Number |
15K15079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Kiyonari Shinichi 名古屋大学, 大学院医学(系)研究科(研究院), 助教 (70570836)
Takeuchi Ichiro 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40335146)
Takahashi Yoshiyuki 名古屋大学, 大学院医学(系)研究科(研究院), 教授 (40432273)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 癌 / 発生 / 分化 / 発生・分化 |
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| Outline of Final Research Achievements |
Why does tumor develop without driver gene mutations in pediatric cancers? Its reason remains elusive although it is speculated that epigenetic regulations are involved. To address this question, we developed a new method, i.e., tumor sphere culture from very early stages of carcinogenesis. We found that cancer has developed as early as in mid-gestation period in the neuroblastoma model TH-MYCN mice. Furthermore, we found that epigenetic regulations are indeed critical for neuroblastoma development, and that EZH2 is a molecular target for its treatment.
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