Mechanisms of carcinogenesis through deviation from normal development
Project/Area Number |
15K15079
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
Kiyonari Shinichi 名古屋大学, 大学院医学(系)研究科(研究院), 助教 (70570836)
Takeuchi Ichiro 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40335146)
Takahashi Yoshiyuki 名古屋大学, 大学院医学(系)研究科(研究院), 教授 (40432273)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 癌 / 発生 / 分化 / 発生・分化 |
Outline of Final Research Achievements |
Why does tumor develop without driver gene mutations in pediatric cancers? Its reason remains elusive although it is speculated that epigenetic regulations are involved. To address this question, we developed a new method, i.e., tumor sphere culture from very early stages of carcinogenesis. We found that cancer has developed as early as in mid-gestation period in the neuroblastoma model TH-MYCN mice. Furthermore, we found that epigenetic regulations are indeed critical for neuroblastoma development, and that EZH2 is a molecular target for its treatment.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.2017
Author(s)
Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114(14)
Issue: 14
Pages: 114-114
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.2017
Author(s)
Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 42257-42257
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.2017
Author(s)
Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.
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Journal Title
Am J Pathol.
Volume: 187(4)
Issue: 4
Pages: 740-751
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.2016
Author(s)
Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 31615-31615
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease.2016
Author(s)
Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I.
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Journal Title
Hypertension.
Volume: 67(5)
Issue: 5
Pages: 857-865
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice.2016
Author(s)
Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 4
Pages: 636-646
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis.2015
Author(s)
Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, Niimi S, Saeki H, Tokunaga E, Oki E, Morita M, Kadomatsu K, Maehara Y, Kitao H
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Journal Title
Mol Cancer Ther.
Volume: 14
Pages: 2332-2342
Related Report
Peer Reviewed / Acknowledgement Compliant
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