• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Implication of oxidative damage in nucleic acids and its defense mechanisms for development of brain dysfunction which may be caused by chronic kidney disease

Research Project

Project/Area Number 15K15085
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKyushu University

Principal Investigator

Nakabeppu Yusaku  九州大学, 生体防御医学研究所, 教授 (30180350)

Co-Investigator(Renkei-kenkyūsha) Kazuhiko Tsuruya  九州大学, 医学研究院, 准教授 (20372740)
Research Collaborator Naoki Haruyama  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords認知症 / 慢性腎不全 / MTH1 / OGG1 / 8-オキソグアニン / 8-オキシグアニン
Outline of Final Research Achievements

Increased oxidative stress in brains of patients with chronic kidney disease (CKD), which frequently occurs in elderly people, has been implicated as one of the causes for dementia. Neurodegeneration of hippocampal CA3 region has been reported in brain of CKD model mouse generated by ligation of left renal artery and partial removal of right kidney. In this study, we examined whether oxidative damage in nucleic acids play a role for developing the brain dysfunction in this CKD model using mice lacking genes for defense and repair of oxidative damage in nucleic acids. As a result, neither cognitive dysfunction nor degenerative lesions of the brain were recognized in this CKD model, and even in mice lacking genes for defense and repair of oxidative damage in nucleic acids, CKD did not enhance brain dysfunction. From the results, we concluded that brain dysfunction is not induced in this CKD model mouse.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.2017

    • Author(s)
      Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y.
    • Journal Title

      Mech Ageing Dev.

      Volume: 161 Pages: 95-104

    • DOI

      10.1016/j.mad.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.2016

    • Author(s)
      S. Oka, J. Leon, K. Sakumi, T. Ide, D. Kang, F.M. LaFerla, and Y. Nakabeppu
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 37889-37889

    • DOI

      10.1038/srep37889

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?2016

    • Author(s)
      Y. Nakabeppu, E. Ohta, N. Abolhassani
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 印刷中 Pages: 151-158

    • DOI

      10.1016/j.freeradbiomed.2016.11.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ゲノムに蓄積した8-oxoguanine に起因する病態とその防御機構 -発がんから神経変性まで-2016

    • Author(s)
      中別府 雄作
    • Journal Title

      基礎老化研究

      Volume: 40 Pages: 23-31

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016

    • Author(s)
      Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
    • Journal Title

      Scientific Reports

      Volume: 25 Issue: 1 Pages: 22086-22086

    • DOI

      10.1038/srep22086

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] アルツハイマー病脳におけるインスリン枯渇とミトコンドリア機能不全に起因する酸化ストレスの分子病態2017

    • Author(s)
      中別府雄作
    • Organizer
      第13回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Oxidative DNA damage and repair in carcinogenesis and neurodegeneration2017

    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016

    • Author(s)
      岡 素雅子, 盛 子敬, フリオ レオン, 土本 大介, 作見 邦彦, 中別府 雄作
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 8-Oxoguanine accumulated in mitochondrial DNA disturbs neuritic regeneration of cultured adult mouse cortical neurons under conditions of oxidative stress2015

    • Author(s)
      Julio Leon, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
    • Organizer
      45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cortical neurons isolated from adult Mth1/Ogg1-double-knockout mouse exhibit impaired neurite regeneration under conditions of oxidative stress2015

    • Author(s)
      Julio Jesusu Leon Incio, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Book] Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases. in The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design2017

    • Author(s)
      Y Nakabeppu
    • Total Pages
      34
    • Publisher
      World Scientific Publishing Co., Pte. Ltd. Singapore
    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学生体防御医学研究所脳機能制御学分野

    • URL

      http://www.bioreg.kyushu-u.ac.jp/nfg/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学 生体防御医学研究所 脳機能制御学分野

    • URL

      http://www.bioreg.kyushu-u.ac.jp/nfg/index.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 九州大学 研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K000856/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi